The HMG-CoA Reductase gene and lipid and lipoprotein levels: The multi-ethnic study of atherosclerosis

Yi Chun Chen, Yii Der I Chen, Xiaohui Li, Wendy S Post, David Herrington, Joseph F. Polak, Jerome I. Rotter, Kent D. Taylor

Research output: Contribution to journalArticle

Abstract

HMG-CoA reductase (HMGCR) is an enzyme involved in cholesterol synthesis. To investigate the contribution of the HMGCR gene to lipids and lipoprotein subfractions in different ethnicities, we performed an association study in the Multi-Ethnic Study of Atherosclerosis (MESA). In total, 2,444 MESA subjects [597 African-Americans (AA), 627 Chinese-Americans (CHA), 612 European-Americans (EA), and 608 Hispanic-Americans (HA)] without statin use were included. Participants had measurements of blood pressure, anthropometry, and fasting blood samples. Subjects were genotyped for 10 single nucleotide polymorphisms (SNPs). After excluding SNPs with minor allele frequency

Original languageEnglish (US)
Pages (from-to)733-743
Number of pages11
JournalLipids
Volume44
Issue number8
DOIs
StatePublished - Aug 2009

Fingerprint

Hydroxymethylglutaryl CoA Reductases
Polymorphism
Lipoproteins
Single Nucleotide Polymorphism
Atherosclerosis
Nucleotides
Genes
Anthropometry
Lipids
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Asian Americans
Blood pressure
Hispanic Americans
Gene Frequency
African Americans
Fasting
Blood
Cholesterol
Association reactions
Blood Pressure

Keywords

  • Association study
  • Cholesterol
  • Hydroxymethylglutaryl CoA reductases
  • Low-density lipoprotein size
  • Triglyceride

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Organic Chemistry

Cite this

Chen, Y. C., Chen, Y. D. I., Li, X., Post, W. S., Herrington, D., Polak, J. F., ... Taylor, K. D. (2009). The HMG-CoA Reductase gene and lipid and lipoprotein levels: The multi-ethnic study of atherosclerosis. Lipids, 44(8), 733-743. https://doi.org/10.1007/s11745-009-3314-6

The HMG-CoA Reductase gene and lipid and lipoprotein levels : The multi-ethnic study of atherosclerosis. / Chen, Yi Chun; Chen, Yii Der I; Li, Xiaohui; Post, Wendy S; Herrington, David; Polak, Joseph F.; Rotter, Jerome I.; Taylor, Kent D.

In: Lipids, Vol. 44, No. 8, 08.2009, p. 733-743.

Research output: Contribution to journalArticle

Chen, YC, Chen, YDI, Li, X, Post, WS, Herrington, D, Polak, JF, Rotter, JI & Taylor, KD 2009, 'The HMG-CoA Reductase gene and lipid and lipoprotein levels: The multi-ethnic study of atherosclerosis', Lipids, vol. 44, no. 8, pp. 733-743. https://doi.org/10.1007/s11745-009-3314-6
Chen, Yi Chun ; Chen, Yii Der I ; Li, Xiaohui ; Post, Wendy S ; Herrington, David ; Polak, Joseph F. ; Rotter, Jerome I. ; Taylor, Kent D. / The HMG-CoA Reductase gene and lipid and lipoprotein levels : The multi-ethnic study of atherosclerosis. In: Lipids. 2009 ; Vol. 44, No. 8. pp. 733-743.
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