The hidden burden of dengue and chikungunya in chennai, India

Isabel Rodríguez-Barraquer, Sunil Solomon, Periaswamy Kuganantham, Aylur Kailasom Srikrishnan, Canjeevaram K. Vasudevan, Syed H. Qbal, Pachamuthu Balakrishnan, Suniti Solomon, Shruti Hemendra Mehta, Derek A T Cummings

Research output: Contribution to journalArticle

Abstract

Background Dengue and chikungunya are rapidly expanding viruses transmitted by mosquitoes of the genus Aedes. Few epidemiological studies have examined the extent of transmission of these infections in South India despite an increase in the number of reported cases, and a high suitability for transmission. Methods and findings We conducted a household-based seroprevalence survey among 1010 individuals aged 5-40 years living in fifty randomly selected spatial locations in Chennai, Tamil Nadu. Participants were asked to provide a venous blood sample and to complete a brief questionnaire with basic demographic and daily activity information. Previous exposure to dengue and chikungunya was determined using IgG indirect ELISA (Panbio) and IgG ELISA (Novatec), respectively. We used this data to estimate key transmission parameters (force of infection and basic reproductive number) and to explore factors associated with seropositivity. While only 1% of participants reported history of dengue and 20% of chikungunya, we found that 93% (95%CI 89-95%) of participants were seropositive to dengue virus, and 44% (95%CI 37-50%) to chikungunya. Age-specific seroprevalence was consistent with long-tem, endemic circulation of dengue and suggestive of epidemic chikungunya transmission. Seropositivity to dengue and chikungunya were significantly correlated, even after adjusting for individual and household factors. We estimate that 23% of the susceptible population gets infected by dengue each year, corresponding to approximately 228,000 infections. This transmission intensity is significantly higher than that estimated in known hyperendemic settings in Southeast Asia and the Americas. Conclusions These results provide unprecedented insight into the very high transmission potential of dengue and chikungunya in Chennai and underscore the need for enhanced surveillance and control methods.

Original languageEnglish (US)
Article numberA035
Pages (from-to)1-15
Number of pages15
JournalPLoS Neglected Tropical Diseases
Volume9
Issue number7
DOIs
StatePublished - 2015

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Dengue
India
Seroepidemiologic Studies
Immunoglobulin G
Enzyme-Linked Immunosorbent Assay
Southeastern Asia
Dengue Virus
Infectious Disease Transmission
Aedes
Infection
Culicidae
Epidemiologic Studies
Demography
Viruses
Population

ASJC Scopus subject areas

  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • Pharmacology, Toxicology and Pharmaceutics(all)

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Rodríguez-Barraquer, I., Solomon, S., Kuganantham, P., Srikrishnan, A. K., Vasudevan, C. K., Qbal, S. H., ... Cummings, D. A. T. (2015). The hidden burden of dengue and chikungunya in chennai, India. PLoS Neglected Tropical Diseases, 9(7), 1-15. [A035]. https://doi.org/10.1371/journal.pntd.0003906

The hidden burden of dengue and chikungunya in chennai, India. / Rodríguez-Barraquer, Isabel; Solomon, Sunil; Kuganantham, Periaswamy; Srikrishnan, Aylur Kailasom; Vasudevan, Canjeevaram K.; Qbal, Syed H.; Balakrishnan, Pachamuthu; Solomon, Suniti; Mehta, Shruti Hemendra; Cummings, Derek A T.

In: PLoS Neglected Tropical Diseases, Vol. 9, No. 7, A035, 2015, p. 1-15.

Research output: Contribution to journalArticle

Rodríguez-Barraquer, I, Solomon, S, Kuganantham, P, Srikrishnan, AK, Vasudevan, CK, Qbal, SH, Balakrishnan, P, Solomon, S, Mehta, SH & Cummings, DAT 2015, 'The hidden burden of dengue and chikungunya in chennai, India', PLoS Neglected Tropical Diseases, vol. 9, no. 7, A035, pp. 1-15. https://doi.org/10.1371/journal.pntd.0003906
Rodríguez-Barraquer I, Solomon S, Kuganantham P, Srikrishnan AK, Vasudevan CK, Qbal SH et al. The hidden burden of dengue and chikungunya in chennai, India. PLoS Neglected Tropical Diseases. 2015;9(7):1-15. A035. https://doi.org/10.1371/journal.pntd.0003906
Rodríguez-Barraquer, Isabel ; Solomon, Sunil ; Kuganantham, Periaswamy ; Srikrishnan, Aylur Kailasom ; Vasudevan, Canjeevaram K. ; Qbal, Syed H. ; Balakrishnan, Pachamuthu ; Solomon, Suniti ; Mehta, Shruti Hemendra ; Cummings, Derek A T. / The hidden burden of dengue and chikungunya in chennai, India. In: PLoS Neglected Tropical Diseases. 2015 ; Vol. 9, No. 7. pp. 1-15.
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abstract = "Background Dengue and chikungunya are rapidly expanding viruses transmitted by mosquitoes of the genus Aedes. Few epidemiological studies have examined the extent of transmission of these infections in South India despite an increase in the number of reported cases, and a high suitability for transmission. Methods and findings We conducted a household-based seroprevalence survey among 1010 individuals aged 5-40 years living in fifty randomly selected spatial locations in Chennai, Tamil Nadu. Participants were asked to provide a venous blood sample and to complete a brief questionnaire with basic demographic and daily activity information. Previous exposure to dengue and chikungunya was determined using IgG indirect ELISA (Panbio) and IgG ELISA (Novatec), respectively. We used this data to estimate key transmission parameters (force of infection and basic reproductive number) and to explore factors associated with seropositivity. While only 1{\%} of participants reported history of dengue and 20{\%} of chikungunya, we found that 93{\%} (95{\%}CI 89-95{\%}) of participants were seropositive to dengue virus, and 44{\%} (95{\%}CI 37-50{\%}) to chikungunya. Age-specific seroprevalence was consistent with long-tem, endemic circulation of dengue and suggestive of epidemic chikungunya transmission. Seropositivity to dengue and chikungunya were significantly correlated, even after adjusting for individual and household factors. We estimate that 23{\%} of the susceptible population gets infected by dengue each year, corresponding to approximately 228,000 infections. This transmission intensity is significantly higher than that estimated in known hyperendemic settings in Southeast Asia and the Americas. Conclusions These results provide unprecedented insight into the very high transmission potential of dengue and chikungunya in Chennai and underscore the need for enhanced surveillance and control methods.",
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T1 - The hidden burden of dengue and chikungunya in chennai, India

AU - Rodríguez-Barraquer, Isabel

AU - Solomon, Sunil

AU - Kuganantham, Periaswamy

AU - Srikrishnan, Aylur Kailasom

AU - Vasudevan, Canjeevaram K.

AU - Qbal, Syed H.

AU - Balakrishnan, Pachamuthu

AU - Solomon, Suniti

AU - Mehta, Shruti Hemendra

AU - Cummings, Derek A T

PY - 2015

Y1 - 2015

N2 - Background Dengue and chikungunya are rapidly expanding viruses transmitted by mosquitoes of the genus Aedes. Few epidemiological studies have examined the extent of transmission of these infections in South India despite an increase in the number of reported cases, and a high suitability for transmission. Methods and findings We conducted a household-based seroprevalence survey among 1010 individuals aged 5-40 years living in fifty randomly selected spatial locations in Chennai, Tamil Nadu. Participants were asked to provide a venous blood sample and to complete a brief questionnaire with basic demographic and daily activity information. Previous exposure to dengue and chikungunya was determined using IgG indirect ELISA (Panbio) and IgG ELISA (Novatec), respectively. We used this data to estimate key transmission parameters (force of infection and basic reproductive number) and to explore factors associated with seropositivity. While only 1% of participants reported history of dengue and 20% of chikungunya, we found that 93% (95%CI 89-95%) of participants were seropositive to dengue virus, and 44% (95%CI 37-50%) to chikungunya. Age-specific seroprevalence was consistent with long-tem, endemic circulation of dengue and suggestive of epidemic chikungunya transmission. Seropositivity to dengue and chikungunya were significantly correlated, even after adjusting for individual and household factors. We estimate that 23% of the susceptible population gets infected by dengue each year, corresponding to approximately 228,000 infections. This transmission intensity is significantly higher than that estimated in known hyperendemic settings in Southeast Asia and the Americas. Conclusions These results provide unprecedented insight into the very high transmission potential of dengue and chikungunya in Chennai and underscore the need for enhanced surveillance and control methods.

AB - Background Dengue and chikungunya are rapidly expanding viruses transmitted by mosquitoes of the genus Aedes. Few epidemiological studies have examined the extent of transmission of these infections in South India despite an increase in the number of reported cases, and a high suitability for transmission. Methods and findings We conducted a household-based seroprevalence survey among 1010 individuals aged 5-40 years living in fifty randomly selected spatial locations in Chennai, Tamil Nadu. Participants were asked to provide a venous blood sample and to complete a brief questionnaire with basic demographic and daily activity information. Previous exposure to dengue and chikungunya was determined using IgG indirect ELISA (Panbio) and IgG ELISA (Novatec), respectively. We used this data to estimate key transmission parameters (force of infection and basic reproductive number) and to explore factors associated with seropositivity. While only 1% of participants reported history of dengue and 20% of chikungunya, we found that 93% (95%CI 89-95%) of participants were seropositive to dengue virus, and 44% (95%CI 37-50%) to chikungunya. Age-specific seroprevalence was consistent with long-tem, endemic circulation of dengue and suggestive of epidemic chikungunya transmission. Seropositivity to dengue and chikungunya were significantly correlated, even after adjusting for individual and household factors. We estimate that 23% of the susceptible population gets infected by dengue each year, corresponding to approximately 228,000 infections. This transmission intensity is significantly higher than that estimated in known hyperendemic settings in Southeast Asia and the Americas. Conclusions These results provide unprecedented insight into the very high transmission potential of dengue and chikungunya in Chennai and underscore the need for enhanced surveillance and control methods.

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