The heterogeneity of lipid metabolism in cancer

Joshua K. Park, Nathan J. Coffey, Aaron Limoges, Quy Hoa Le Thi

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Fatty acid synthesis is upregulated in cancer.The mitochondrial citrate transporter protein (CTP) protects mitochondrial function in cancer.ATP citrate lyase (ACLY) is upregulated in cancer.Multifaceted effects of inhibiting acetyl-CoA carboxylase (ACC) in cancer.First fatty acid synthase (FAS) inhibitor TVB-2640 in clinical trials for cancer.What markers can predict cancer cell sensitivity to lipid synthesis inhibition?Tumor microenvironment impacts the sensitivity of cancer cells to lipid synthesis inhibitors.The efficacy of inhibiting cholesterol synthesis with adjuvant statins is variable.Fatty acid uptake is associated with metastasis.Targeting FAO for cancer therapy may be achieved by inhibiting carnitine palmitoyltransferase 1.Carnitine palmitoyltransferase 1 (CPT1) inhibitors are now in clinical trials. FAO occurs at the peroxisome where peroxisome proliferator-activated receptors (PPARs) act as ligand-activated transcription factors.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages33-55
Number of pages23
DOIs
StatePublished - Jan 1 2018

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1063
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Cancer metabolism
  • Fatty acid oxidation
  • Fatty acid uptake
  • Lipid synthesis
  • Lipidomics
  • Metastasis
  • Tumor heterogeneity

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Park, J. K., Coffey, N. J., Limoges, A., & Le Thi, Q. H. (2018). The heterogeneity of lipid metabolism in cancer. In Advances in Experimental Medicine and Biology (pp. 33-55). (Advances in Experimental Medicine and Biology; Vol. 1063). Springer New York LLC. https://doi.org/10.1007/978-3-319-77736-8_3