The Heterogeneity of Breast Cancer Metabolism

Jessica Tan, Anne Le

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Despite advances in screening, therapy, and surveillance that have improved patient survival rates, breast cancer is still the most commonly diagnosed cancer and the second leading cause of cancer mortality among women [1]. Breast cancer is a highly heterogeneous disease rooted in a genetic basis, influenced by extrinsic stimuli, and reflected in clinical behavior. The diversity of breast cancer hormone receptor status and the expression of surface molecules have guided therapy decisions for decades; however, subtype-specific treatment often yields diverse responses due to varying tumor evolution and malignant potential. Although the mechanisms behind breast cancer heterogeneity is not well understood, available evidence suggests that studying breast cancer metabolism has the potential to provide valuable insights into the causes of these variations as well as viable targets for intervention.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer
Pages89-101
Number of pages13
DOIs
StatePublished - 2021

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1311
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Breast cancer
  • Choline metabolism
  • Estrogen metabolism
  • Estrogen receptor status
  • Glycolytic upregulation
  • Intratumoral heterogeneity
  • Metabolic adaptivity
  • Metabolic fingerprint
  • Serine biosynthesis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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