TY - CHAP
T1 - The Heterogeneity of Breast Cancer Metabolism
AU - Tan, Jessica
AU - Le, Anne
N1 - Publisher Copyright:
© 2021, The Author(s).
PY - 2021
Y1 - 2021
N2 - Despite advances in screening, therapy, and surveillance that have improved patient survival rates, breast cancer is still the most commonly diagnosed cancer and the second leading cause of cancer mortality among women [1]. Breast cancer is a highly heterogeneous disease rooted in a genetic basis, influenced by extrinsic stimuli, and reflected in clinical behavior. The diversity of breast cancer hormone receptor status and the expression of surface molecules have guided therapy decisions for decades; however, subtype-specific treatment often yields diverse responses due to varying tumor evolution and malignant potential. Although the mechanisms behind breast cancer heterogeneity is not well understood, available evidence suggests that studying breast cancer metabolism has the potential to provide valuable insights into the causes of these variations as well as viable targets for intervention.
AB - Despite advances in screening, therapy, and surveillance that have improved patient survival rates, breast cancer is still the most commonly diagnosed cancer and the second leading cause of cancer mortality among women [1]. Breast cancer is a highly heterogeneous disease rooted in a genetic basis, influenced by extrinsic stimuli, and reflected in clinical behavior. The diversity of breast cancer hormone receptor status and the expression of surface molecules have guided therapy decisions for decades; however, subtype-specific treatment often yields diverse responses due to varying tumor evolution and malignant potential. Although the mechanisms behind breast cancer heterogeneity is not well understood, available evidence suggests that studying breast cancer metabolism has the potential to provide valuable insights into the causes of these variations as well as viable targets for intervention.
KW - Breast cancer
KW - Choline metabolism
KW - Estrogen metabolism
KW - Estrogen receptor status
KW - Glycolytic upregulation
KW - Intratumoral heterogeneity
KW - Metabolic adaptivity
KW - Metabolic fingerprint
KW - Serine biosynthesis
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U2 - 10.1007/978-3-030-65768-0_6
DO - 10.1007/978-3-030-65768-0_6
M3 - Chapter
C2 - 34014536
AN - SCOPUS:85106447816
T3 - Advances in Experimental Medicine and Biology
SP - 89
EP - 101
BT - Advances in Experimental Medicine and Biology
PB - Springer
ER -