The healing of facial bone fractures by the process of secondary union

Linda J. Rever, Paul Manson, Mark A. Randolph, Michael J. Yaremchuk, Andrew Weiland, John H. Siegel

Research output: Contribution to journalArticle

Abstract

The mechanism of healing of facial bone fractures was investigated in a rabbit model. Twelve New Zealand white rabbits underwent surgically induced fractures of the right infraorbital rim and fracture ostectomies (4 to 5 mm) of the left infraorbital rim. Animals were sacrificed 2, 4, and 8 weeks postfracture. Bone, including periosteum, obtained from each fracture or fracture ostectomy site was divided longitudinally for hematoxylin and eosin staining, fluorescent microscopy, microangiography, and microradiography. Sequential fluorochrome labels of oxytetracycline (30 mg/kg), alizarin complexone (30 mg/ kg), DCAF (20 mg/kg), and xylenol orange (90 mg/kg) were administered 24 hours preoperatively and at 1, 2, 4, and 8 weeks postfracture. All fracture and fracture ostectomy sites demonstrated vascular ingrowth, mineralization, and woven bone formation by 2 to 4 weeks postoperatively, beginning with a cartilage precursor. Subsequently, the woven bone was replaced with remodeled lamellar bone, resulting in complete bony healing by 8 weeks postoperatively. These steps were substantiated by microscopic, microradiographic, and radiologic examination of the specimens. This study demonstrates that fractures of the facial bones in a rabbit model heal by a process of new bone formation that resembles secondary union in endochondral bones.

Original languageEnglish (US)
Pages (from-to)451-458
Number of pages8
JournalPlastic and Reconstructive Surgery
Volume87
Issue number3
StatePublished - 1991

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Facial Bones
Bone Fractures
Bone and Bones
Rabbits
Osteogenesis
Microradiography
Oxytetracycline
Periosteum
Hematoxylin
Eosine Yellowish-(YS)
Fluorescent Dyes
Cartilage
Blood Vessels
Microscopy
Staining and Labeling

ASJC Scopus subject areas

  • Surgery

Cite this

Rever, L. J., Manson, P., Randolph, M. A., Yaremchuk, M. J., Weiland, A., & Siegel, J. H. (1991). The healing of facial bone fractures by the process of secondary union. Plastic and Reconstructive Surgery, 87(3), 451-458.

The healing of facial bone fractures by the process of secondary union. / Rever, Linda J.; Manson, Paul; Randolph, Mark A.; Yaremchuk, Michael J.; Weiland, Andrew; Siegel, John H.

In: Plastic and Reconstructive Surgery, Vol. 87, No. 3, 1991, p. 451-458.

Research output: Contribution to journalArticle

Rever, LJ, Manson, P, Randolph, MA, Yaremchuk, MJ, Weiland, A & Siegel, JH 1991, 'The healing of facial bone fractures by the process of secondary union', Plastic and Reconstructive Surgery, vol. 87, no. 3, pp. 451-458.
Rever LJ, Manson P, Randolph MA, Yaremchuk MJ, Weiland A, Siegel JH. The healing of facial bone fractures by the process of secondary union. Plastic and Reconstructive Surgery. 1991;87(3):451-458.
Rever, Linda J. ; Manson, Paul ; Randolph, Mark A. ; Yaremchuk, Michael J. ; Weiland, Andrew ; Siegel, John H. / The healing of facial bone fractures by the process of secondary union. In: Plastic and Reconstructive Surgery. 1991 ; Vol. 87, No. 3. pp. 451-458.
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