The guanosine binding site of the Tetrahymena ribozyme

François Michel, Maya Hanna, Rachel Green, David P. Bartel, Jack W. Szostak

Research output: Contribution to journalArticle

Abstract

The self-splicing Group I introns have a highly specific binding site for the substrate guanosine. Mutant versions of the Tetrahymena ribozyme have been used in combination with guanosine analogues to identify the nucleotide in the ribozyme that is primarily responsible for recognition of the guanine base.

Original languageEnglish (US)
Pages (from-to)391-395
Number of pages5
JournalNature
Volume342
Issue number6248
DOIs
StatePublished - Jan 1 1989
Externally publishedYes

ASJC Scopus subject areas

  • General

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    Michel, F., Hanna, M., Green, R., Bartel, D. P., & Szostak, J. W. (1989). The guanosine binding site of the Tetrahymena ribozyme. Nature, 342(6248), 391-395. https://doi.org/10.1038/342391a0