The guanosine binding site of the Tetrahymena ribozyme

François Michel; Maya Hanna; Rachel Green; David P. Bartel; Jack W. Szostak

doi:10.1038/342391a0

The guanosine binding site of the Tetrahymena ribozyme

François Michel, Maya Hanna, Rachel Green, David P. Bartel, Jack W. Szostak

Research output: Contribution to journal › Article › peer-review

320 Scopus citations

Abstract

The self-splicing Group I introns have a highly specific binding site for the substrate guanosine. Mutant versions of the Tetrahymena ribozyme have been used in combination with guanosine analogues to identify the nucleotide in the ribozyme that is primarily responsible for recognition of the guanine base.

Original language	English (US)
Pages (from-to)	391-395
Number of pages	5
Journal	Nature
Volume	342
Issue number	6248
DOIs	https://doi.org/10.1038/342391a0
State	Published - 1989
Externally published	Yes

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title = "The guanosine binding site of the Tetrahymena ribozyme",

abstract = "The self-splicing Group I introns have a highly specific binding site for the substrate guanosine. Mutant versions of the Tetrahymena ribozyme have been used in combination with guanosine analogues to identify the nucleotide in the ribozyme that is primarily responsible for recognition of the guanine base.",

author = "Fran{\c c}ois Michel and Maya Hanna and Rachel Green and Bartel, {David P.} and Szostak, {Jack W.}",

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AU - Green, Rachel

AU - Bartel, David P.

AU - Szostak, Jack W.

PY - 1989

Y1 - 1989

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AB - The self-splicing Group I introns have a highly specific binding site for the substrate guanosine. Mutant versions of the Tetrahymena ribozyme have been used in combination with guanosine analogues to identify the nucleotide in the ribozyme that is primarily responsible for recognition of the guanine base.

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ER -

The guanosine binding site of the Tetrahymena ribozyme

Abstract

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