The G894-T894 polymorphism in the gene for endothelial nitric oxide synthase and blood pressure in lead-exposed workers from Korea

Mark E. Lustberg, Brian S. Schwartz, Byung Kook Lee, Andrew C. Todd, Ellen K. Silbergeld

Research output: Contribution to journalArticlepeer-review

Abstract

We evaluated whether the G894-T894 polymorphism in exon 7 of the endothelial nitric oxide synthase (eNOS) gene is associated with blood pressure or modifies the relation between lead dose and blood pressure in 803 lead workers in Korea. A total of 84.9% of individuals were homozygous GG, 14.4% heterozygous GT, and 0.8% homozygous TT. The T894 allele was not significantly associated with systolic or diastolic blood pressure. The prevalence of hypertension did not differ by T894 status (OR = 0.82; 95% CI = 0.50-1.37). There was no evidence of effect modification by eNOS genotype on relations of lead dose with blood pressure. These data provide no evidence that the T894 allele is associated with higher blood pressure or modifies the association of lead dose with blood pressure.

Original languageEnglish (US)
Pages (from-to)584-590
Number of pages7
JournalJournal of occupational and environmental medicine
Volume46
Issue number6
DOIs
StatePublished - Jun 2004

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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