We evaluated whether the G894-T894 polymorphism in exon 7 of the endothelial nitric oxide synthase (eNOS) gene is associated with blood pressure or modifies the relation between lead dose and blood pressure in 803 lead workers in Korea. A total of 84.9% of individuals were homozygous GG, 14.4% heterozygous GT, and 0.8% homozygous TT. The T894 allele was not significantly associated with systolic or diastolic blood pressure. The prevalence of hypertension did not differ by T894 status (OR = 0.82; 95% CI = 0.50-1.37). There was no evidence of effect modification by eNOS genotype on relations of lead dose with blood pressure. These data provide no evidence that the T894 allele is associated with higher blood pressure or modifies the association of lead dose with blood pressure.
|Original language||English (US)|
|Number of pages||7|
|Journal||Journal of occupational and environmental medicine|
|State||Published - Jun 2004|
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health