The gonadotropin-releasing hormone agonist stimulation test - A sensitive predictor of performance in the flare-up in vitro fertilization cycle

K. L. Winslow, J. P. Toner, R. G. Brzyski, S. C. Oehninger, A. A. Acosta, S. J. Muasher

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To evaluate the initial versus early pattern of estradiol (E2) change after administration of a gonadotropin-releasing hormone agonist (GnRH-a), i.e., the GnRH-a stimulation test versus E2 pattern, respectively, as predictors of ovarian response and pregnancy in in vitro fertilization (IVF) patients stimulated with a flare-up protocol. Design: Prospective study in a consecutive group of patients. Setting: Tertiary care, institutional setting. Patients: Two hundred twenty-eight patients entered and completed the study. The only patients excluded from study were those anticipated to have polycystic ovarian disease, those with a single ovary, or those with an ovarian cyst(s). Interventions: Patients were stimulated with a GnRH-a flare-up protocol beginning on menstrual day 2. Main Outcome: Evaluation of the GnRH-a stimulation test and the E2 pattern as predictors of the number of mature oocytes retrieved and pregnancy. Results: The GnRH-a stimulation test but not the E2 pattern was predictive of the number of mature oocytes retrieved (r = 0.53, P < 1 x 10-5) and pregnancy (χ2 = 8.5, P = 0.04). The E2 pattern was predictive of the duration and number of ampules of gonadotropin required for stimulation. Conclusion: The GnRH-a stimulation test is a sensitive predictor of performance in the flare-up IVF cycle.

Original languageEnglish (US)
Pages (from-to)711-717
Number of pages7
JournalFertility and sterility
Volume56
Issue number4
DOIs
StatePublished - Jan 1 1991

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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