The Golgi complex in stress and death

Research output: Contribution to journalArticle

Abstract

The Golgi complex is a central organelle of the secretory pathway where sorting and processing of cargo occurs. While Golgi structure is important for the efficient processing of secretory cargo, the unusual organization suggests additional potential functions. The Golgi is disassembled after various cellular stresses, and we hypothesize that Golgi disassembly activates a stress signaling pathway. This pathway would function to correct the stress if possible, with irreparable stress resulting in apoptosis. Neurons appear to be particularly sensitive to Golgi stress; early disassembly of the organelle correlates with many neurodegenerative diseases. Here, Golgi stress and potential signaling pathways to the nucleus are reviewed.

Original languageEnglish (US)
Article number421
JournalFrontiers in Neuroscience
Volume9
Issue numberNOV
DOIs
StatePublished - 2015

Fingerprint

Golgi Apparatus
Organelles
Secretory Pathway
Neurodegenerative Diseases
Apoptosis
Neurons

Keywords

  • Apoptosis
  • Disassembly
  • Golgi complex
  • Signaling
  • Stress

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

The Golgi complex in stress and death. / Machamer, Carolyn E.

In: Frontiers in Neuroscience, Vol. 9, No. NOV, 421, 2015.

Research output: Contribution to journalArticle

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