The glycosphingolipids of human prostate tissue

T. Shiraishi, M. T. Kinter, S. E. Mills, M. C. Lippert, G. S. Bova, W. W. Young

Research output: Contribution to journalArticlepeer-review

Abstract

Neutral glycolipids and gangliosides from surgical samples of benign human prostate tissue were analyzed by chemical, enzymatic and immunostaining procedures. The neutral glycolipids consisted of ceramide mono-, di-, tri- and tetrahexosides of the globo series plus paragloboside. The monosialoganglioside fraction contained GM3 and GM1 plus multiple species of monosialylated lactosamine-containing structures, including sialyl-α-2 → 3paragloboside plus at least two compounds having a non-reducing terminal sialyl α2 → 6Gal linkage. The disialoganglioside fraction contained GD3 as the major component plus GD1a, GD2 and GD1b. GT1b was the major trisialoganglioside.

Original languageEnglish (US)
Pages (from-to)160-169
Number of pages10
JournalBiochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism
Volume961
Issue number2
DOIs
StatePublished - Jul 22 1988

Keywords

  • (Human)
  • Ganglioside
  • Glycosphingolipid
  • Prostate

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Endocrinology

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