@article{391525e4b50b49239a4d83dcbb76eb2f,
title = "The glutamate analogue quisqualic acid is neurotoxic in striatum and hippocampus of immature rat brain",
abstract = "To assess the neurotoxic properties of the glutamate agonist quisqualic acid (QA) in immature brain, we injected this compound (100 nmol QA/l μl) directly into the striatum of 7-day-old rats. QA produced neuronal necrosis and glial infiltration in 14 pups and reduced the size of the striatum and hippocampus on the side of injection. Intracerebral injection of QA provides a new method for producing neuronal lesions in the developing brain.",
keywords = "Hippocampus, Immature brain, Neurotoxic, Quisqualate, Rat, Striatum",
author = "Silverstein, {Faye S.} and Ronni Chen and Johnston, {Michael V.}",
note = "Funding Information: We thank J.T. Greenamyre for helpful discussions. This work was supported by PHS Grants NS 00603 and NS 17642 (M.V.J.), Grant 326 from the United Cerebral Palsy Research and Education Foundation (M.V.J.) and a fellowship from the Medical Research Council of Canada (F.S.S.) 1 Benveniste,H ., Drejer, J., Schousboe, A. and Diemer, N.H., Elevation of the extracellular concentra-tions of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis,J . Neurochem., 43 (I 984) 1369-1374. 2 Campochiaro, P. and Coyle, J.T., Ontogenetic development of kainate neurotoxicity:c orrelates with glutamatergic innervation, Proc. Natl. Acad. Sci. USA, 75 (1978) 2025-2029. 3 Fukada, H., Tanaka, T., Kadima, M., Nakai, H. and Yonemasu, Y., Quisqualic acid-induced hippo-campal seizures in unanesthetized cats, Neurosci. Lett., 59 (1985) 53 59. 4 Greenamyre,J .T., Olson, J.M., Penney, J. and Young, A.B., Autoradiographicc haracterizationof N-methyl-D-aspartate-, quisqualate-and kainate-sensitive glutamate binding sites, J. Pharmacol. Exp. Ther., 233 (1985) 254~263.",
year = "1986",
month = oct,
day = "30",
doi = "10.1016/0304-3940(86)90249-1",
language = "English (US)",
volume = "71",
pages = "13--18",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "1",
}