The glutamate analogue quisqualic acid is neurotoxic in striatum and hippocampus of immature rat brain

Faye S. Silverstein, Ronni Chen, Michael V. Johnston

Research output: Contribution to journalArticlepeer-review

Abstract

To assess the neurotoxic properties of the glutamate agonist quisqualic acid (QA) in immature brain, we injected this compound (100 nmol QA/l μl) directly into the striatum of 7-day-old rats. QA produced neuronal necrosis and glial infiltration in 14 pups and reduced the size of the striatum and hippocampus on the side of injection. Intracerebral injection of QA provides a new method for producing neuronal lesions in the developing brain.

Original languageEnglish (US)
Pages (from-to)13-18
Number of pages6
JournalNeuroscience Letters
Volume71
Issue number1
DOIs
StatePublished - Oct 30 1986
Externally publishedYes

Keywords

  • Hippocampus
  • Immature brain
  • Neurotoxic
  • Quisqualate
  • Rat
  • Striatum

ASJC Scopus subject areas

  • Neuroscience(all)

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