The global impact of SARS-CoV-2 in 181 people with cystic fibrosis

Elliot McClenaghan, Rebecca Cosgriff, Keith Brownlee, Susannah Ahern, Pierre Régis Burgel, Catherine A. Byrnes, Carla Colombo, Harriet Corvol, Stephanie Y. Cheng, Géraldine Daneau, Alexander Elbert, Albert Faro, Christopher H. Goss, Vincent Gulmans, Hector Gutierrez, Isabelle de Monestrol, Andreas Jung, Lutz Nährlich Justus, Nataliya Kashirskaya, Bruce C. MarshallEdward McKone, Peter G. Middleton, Pedro Mondejar-Lopez, M. Dolores Pastor-Vivero, Rita Padoan, Samar Rizvi, Rasa Ruseckaite, Marco Salvatore, Anne L. Stephenson, Luiz Vicente R.da Silva Filho, Joel Melo, Marco Zampoli, Siobhán B. Carr

Research output: Contribution to journalArticlepeer-review

Abstract

With the growing SARS-CoV-2 pandemic, we need to better understand its impact in specific patient groups like those with Cystic Fibrosis (CF). We report on 181 people with CF (32 post-transplant) from 19 countries diagnosed with SARS-CoV-2 prior to 13 June 2020. Infection with SARS-CoV-2 appears to exhibit a similar spectrum of outcomes to that seen in the general population, with 11 people admitted to intensive care (7 post-transplant), and 7 deaths (3 post-transplant). A more severe clinical course may be associated with older age, CF-related diabetes, lower lung function in the year prior to infection, and having received an organ transplant. Whilst outcomes in this large cohort are better than initially feared overall, possibly due to a protective effect of the relatively younger age of the CF population compared to other chronic conditions, SARS-CoV-2 is not a benign disease for all people in this patient group.

Original languageEnglish (US)
Pages (from-to)868-871
Number of pages4
JournalJournal of Cystic Fibrosis
Volume19
Issue number6
DOIs
StatePublished - Nov 2020

Keywords

  • COVID-19
  • Coronavirus
  • Cystic fibrosis
  • SARS-CoV-2
  • Transplant

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine

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