The germline repertoire of T-cell receptor beta-chain genes in patients with multiple sclerosis

W. E. Biddison, S. S. Beall, P. Concannon, P. Charmley, R. A. Gatti, L. E. Hood, H. F. McFarland, D. E. McFarlin

Research output: Contribution to journalArticlepeer-review

Abstract

The T-cell receptor (TCR) beta-chain gene repertoire of 40 multiple sclerosis (MS) patients was compared to that of 100 normal individuals. V-beta probes that represent 14 different V-beta sub-families plus a C-beta probe were used to identify 53 separate beta-chain gene segments. No duplication or deletion of any of these 53 gene segments was found in the MS patients. Restriction fragment length polymorphism (RFLP) alleles detected by V-beta 8, V-beta 11 and C-beta probes defined 8 different beta-chain haplotypes. The distribution of these haplotypes in Caucasian MS patients and normal individuals was significantly different (p = 0.012). Comparison of the DR2+ subset of MS patients (n = 32) to a second group of 43 Caucasian DR2+ normal individuals revealed that the distribution of these beta-chain haplotypes was significantly different in these two populations (p = 0.015). These results suggest that an MS susceptibility gene(s) may be located in the region of the TCR/beta-chain gene complex.

Original languageEnglish (US)
Pages (from-to)212-215
Number of pages4
JournalResearch in Immunology
Volume140
Issue number2
DOIs
StatePublished - 1989
Externally publishedYes

ASJC Scopus subject areas

  • Immunology

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