The germline repertoire of T cell receptor β-chain genes in patients with chronic progressive multiple sclerosis

Steven S. Beall, Patrick Concannon, Patrick Charmley, Henry F. McFarland, Richard A. Gatti, Leroy E. Hood, Dale E. McFarlin, William E. Biddison

Research output: Contribution to journalArticle

Abstract

The T cell receptor (TcR) β-chain germline gene repertoire of multiple sclerosis (MS) patients was compared to that of 100 normal individuals. No differences in the number of gene segments defined by probes representing 14 different human Vβ subfamilies and the constant region genes were found. The distribution of haplotypes defined by restriction fragment length polymorphism (RFLP) alleles detected with Vβ8, Vβ11, and Cβ probes in the MS patients was significantly different from that found in normal individuals. Because 84% of the MS patients were DR2+, the findings in these patients were compared to a second group of 43 normals who were DR2+. The distribution of TcR haplotypes in MS patients was also significantly different from that in the DR2+ normals. The data suggest that an MS susceptibility gene(s) may be located in the region of the TcR β-chain gene complex.

Original languageEnglish (US)
Pages (from-to)59-66
Number of pages8
JournalJournal of Neuroimmunology
Volume21
Issue number1
DOIs
StatePublished - 1989
Externally publishedYes

Keywords

  • (Human)
  • Antigen
  • Genetics
  • Multiple sclerosis
  • Polymorphism
  • Receptor
  • T cell

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Clinical Neurology
  • Neurology

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  • Cite this

    Beall, S. S., Concannon, P., Charmley, P., McFarland, H. F., Gatti, R. A., Hood, L. E., McFarlin, D. E., & Biddison, W. E. (1989). The germline repertoire of T cell receptor β-chain genes in patients with chronic progressive multiple sclerosis. Journal of Neuroimmunology, 21(1), 59-66. https://doi.org/10.1016/0165-5728(89)90159-8