The germline repertoire of T cell receptor β-chain genes in patients with chronic progressive multiple sclerosis

Steven S. Beall; Patrick Concannon; Patrick Charmley; Henry F. McFarland; Richard A. Gatti; Leroy E. Hood; Dale E. McFarlin; William E. Biddison

doi:10.1016/0165-5728(89)90159-8

The germline repertoire of T cell receptor β-chain genes in patients with chronic progressive multiple sclerosis

Steven S. Beall, Patrick Concannon, Patrick Charmley, Henry F. McFarland, Richard A. Gatti, Leroy E. Hood, Dale E. McFarlin, William E. Biddison

Research output: Contribution to journal › Article › peer-review

139 Scopus citations

Abstract

The T cell receptor (TcR) β-chain germline gene repertoire of multiple sclerosis (MS) patients was compared to that of 100 normal individuals. No differences in the number of gene segments defined by probes representing 14 different human V_β subfamilies and the constant region genes were found. The distribution of haplotypes defined by restriction fragment length polymorphism (RFLP) alleles detected with V_β8, V_β11, and C_β probes in the MS patients was significantly different from that found in normal individuals. Because 84% of the MS patients were DR2⁺, the findings in these patients were compared to a second group of 43 normals who were DR2⁺. The distribution of TcR haplotypes in MS patients was also significantly different from that in the DR2⁺ normals. The data suggest that an MS susceptibility gene(s) may be located in the region of the TcR β-chain gene complex.

Original language	English (US)
Pages (from-to)	59-66
Number of pages	8
Journal	Journal of Neuroimmunology
Volume	21
Issue number	1
DOIs	https://doi.org/10.1016/0165-5728(89)90159-8
State	Published - 1989
Externally published	Yes

Keywords

(Human)
Antigen
Genetics
Multiple sclerosis
Polymorphism
Receptor
T cell

ASJC Scopus subject areas

Immunology
Immunology and Allergy
Clinical Neurology
Neurology

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10.1016/0165-5728(89)90159-8

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title = "The germline repertoire of T cell receptor β-chain genes in patients with chronic progressive multiple sclerosis",

abstract = "The T cell receptor (TcR) β-chain germline gene repertoire of multiple sclerosis (MS) patients was compared to that of 100 normal individuals. No differences in the number of gene segments defined by probes representing 14 different human Vβ subfamilies and the constant region genes were found. The distribution of haplotypes defined by restriction fragment length polymorphism (RFLP) alleles detected with Vβ8, Vβ11, and Cβ probes in the MS patients was significantly different from that found in normal individuals. Because 84% of the MS patients were DR2+, the findings in these patients were compared to a second group of 43 normals who were DR2+. The distribution of TcR haplotypes in MS patients was also significantly different from that in the DR2+ normals. The data suggest that an MS susceptibility gene(s) may be located in the region of the TcR β-chain gene complex.",

keywords = "(Human), Antigen, Genetics, Multiple sclerosis, Polymorphism, Receptor, T cell",

author = "Beall, {Steven S.} and Patrick Concannon and Patrick Charmley and McFarland, {Henry F.} and Gatti, {Richard A.} and Hood, {Leroy E.} and McFarlin, {Dale E.} and Biddison, {William E.}",

year = "1989",

doi = "10.1016/0165-5728(89)90159-8",

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AU - Beall, Steven S.

AU - Concannon, Patrick

AU - Charmley, Patrick

AU - McFarland, Henry F.

AU - Gatti, Richard A.

AU - Hood, Leroy E.

AU - McFarlin, Dale E.

AU - Biddison, William E.

PY - 1989

Y1 - 1989

N2 - The T cell receptor (TcR) β-chain germline gene repertoire of multiple sclerosis (MS) patients was compared to that of 100 normal individuals. No differences in the number of gene segments defined by probes representing 14 different human Vβ subfamilies and the constant region genes were found. The distribution of haplotypes defined by restriction fragment length polymorphism (RFLP) alleles detected with Vβ8, Vβ11, and Cβ probes in the MS patients was significantly different from that found in normal individuals. Because 84% of the MS patients were DR2+, the findings in these patients were compared to a second group of 43 normals who were DR2+. The distribution of TcR haplotypes in MS patients was also significantly different from that in the DR2+ normals. The data suggest that an MS susceptibility gene(s) may be located in the region of the TcR β-chain gene complex.

AB - The T cell receptor (TcR) β-chain germline gene repertoire of multiple sclerosis (MS) patients was compared to that of 100 normal individuals. No differences in the number of gene segments defined by probes representing 14 different human Vβ subfamilies and the constant region genes were found. The distribution of haplotypes defined by restriction fragment length polymorphism (RFLP) alleles detected with Vβ8, Vβ11, and Cβ probes in the MS patients was significantly different from that found in normal individuals. Because 84% of the MS patients were DR2+, the findings in these patients were compared to a second group of 43 normals who were DR2+. The distribution of TcR haplotypes in MS patients was also significantly different from that in the DR2+ normals. The data suggest that an MS susceptibility gene(s) may be located in the region of the TcR β-chain gene complex.

KW - (Human)

KW - Antigen

KW - Genetics

KW - Multiple sclerosis

KW - Polymorphism

KW - Receptor

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The germline repertoire of T cell receptor β-chain genes in patients with chronic progressive multiple sclerosis

Abstract

Keywords

ASJC Scopus subject areas

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