The genomic response of the retinal pigment epithelium to light damage and retinal detachment

Amir Rattner, Leila Toulabi, John Williams, Huimin Yu, Jeremy Nathans

Research output: Contribution to journalArticlepeer-review

Abstract

The retinal pigment epithelium (RPE) plays an essential role in maintaining the health of the retina. The RPE is also the site of pathologic processes in a wide variety of retinal disorders including monogenic retinal dystrophies, age-related macular degeneration, and retinal detachment. Despite intense interest in the RPE, little is known about its molecular response to ocular damage or disease. We have conducted a comprehensive analysis of changes in transcript abundance (the "genomic response") in the murine RPE after light damage. Several dozen transcripts, many related to cell-cell signaling, show significant increases in abundance in response to bright light; transcripts encoding visual cycle proteins show a decrease in abundance. Similar changes are induced by retinal detachment. Environmental and genetic perturbations that modulate the RPE response to bright light suggest that this response is controlled by the retina. In contrast to the response to bright light, the RPE response to retinal detachment overrides these modulatory affects.

Original languageEnglish (US)
Pages (from-to)9880-9889
Number of pages10
JournalJournal of Neuroscience
Volume28
Issue number39
DOIs
StatePublished - Sep 24 2008

Keywords

  • Light damage
  • Microarray
  • Mouse
  • Ocular disease
  • Retinal detachment
  • Retinal pigment epithelium
  • Transcription

ASJC Scopus subject areas

  • Neuroscience(all)

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