The genome sequence of the rice blast fungus Magnaporthe grisea

Ralph A. Dean, Nicholas J. Talbot, Daniel J. Ebbole, Mark L. Farman, Thomas K. Mitchell, Marc J. Orbach, Michael Thon, Resham Kulkarni, Jin Rong Xu, Huaqin Pan, Nick D. Read, Yong Ilwan Lee, Ignazio Carbone, Doug Brown, Yee Oh Yeon, Nicole Donofrio, Seop Jeong Jun, Darren M. Soanes, Slavica Djonovic, Elena Kolomlots & 15 others Cathryn Rehmeyer, Weixl Li, Michael Harding, Soonok Kim, Marc Henri Lebrun, Heidi Bohnert, Sean Coughlan, Jonathan Butler, Sarah Calvo, Li Jun Ma, Robert Nicol, Seth Purcell, Chad Nusbaum, James E. Galagan, Bruce W. Dirren

Research output: Contribution to journalArticle

Abstract

Magnaporthe grisea is the most destructive pathogen of rice worldwide and the principal model organism for elucidating the molecular basis of fungal disease of plants. Here, we report the draft sequence of the M. grisea genome. Analysis of the gene set provides an insight into the adaptations required by a fungus to cause disease. The genome encodes a large and diverse set of secreted proteins, including those defined by unusual carbohydrate-binding domains. This fungus also possesses an expanded family of G-protein-coupled receptors, several new virulence-associated genes and large suites of enzymes involved in secondary metabolism. Consistent with a role in fungal pathogenesis, the expression of several of these genes is upregulated during the early stages of infection-related development. The M. grisea genome has been subject to invasion and proliferation of active transposable elements, reflecting the clonal nature of this fungus imposed by widespread rice cultivation.

Original languageEnglish (US)
Pages (from-to)980-986
Number of pages7
JournalNature
Volume434
Issue number7036
DOIs
StatePublished - Apr 21 2005
Externally publishedYes

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Magnaporthe
Fungi
Genome
Secondary Metabolism
DNA Transposable Elements
Mycoses
G-Protein-Coupled Receptors
Genes
Virulence
Carbohydrates
Gene Expression
Enzymes
Infection
Oryza
Proteins

ASJC Scopus subject areas

  • General

Cite this

Dean, R. A., Talbot, N. J., Ebbole, D. J., Farman, M. L., Mitchell, T. K., Orbach, M. J., ... Dirren, B. W. (2005). The genome sequence of the rice blast fungus Magnaporthe grisea. Nature, 434(7036), 980-986. https://doi.org/10.1038/nature03449

The genome sequence of the rice blast fungus Magnaporthe grisea. / Dean, Ralph A.; Talbot, Nicholas J.; Ebbole, Daniel J.; Farman, Mark L.; Mitchell, Thomas K.; Orbach, Marc J.; Thon, Michael; Kulkarni, Resham; Xu, Jin Rong; Pan, Huaqin; Read, Nick D.; Lee, Yong Ilwan; Carbone, Ignazio; Brown, Doug; Yeon, Yee Oh; Donofrio, Nicole; Jun, Seop Jeong; Soanes, Darren M.; Djonovic, Slavica; Kolomlots, Elena; Rehmeyer, Cathryn; Li, Weixl; Harding, Michael; Kim, Soonok; Lebrun, Marc Henri; Bohnert, Heidi; Coughlan, Sean; Butler, Jonathan; Calvo, Sarah; Ma, Li Jun; Nicol, Robert; Purcell, Seth; Nusbaum, Chad; Galagan, James E.; Dirren, Bruce W.

In: Nature, Vol. 434, No. 7036, 21.04.2005, p. 980-986.

Research output: Contribution to journalArticle

Dean, RA, Talbot, NJ, Ebbole, DJ, Farman, ML, Mitchell, TK, Orbach, MJ, Thon, M, Kulkarni, R, Xu, JR, Pan, H, Read, ND, Lee, YI, Carbone, I, Brown, D, Yeon, YO, Donofrio, N, Jun, SJ, Soanes, DM, Djonovic, S, Kolomlots, E, Rehmeyer, C, Li, W, Harding, M, Kim, S, Lebrun, MH, Bohnert, H, Coughlan, S, Butler, J, Calvo, S, Ma, LJ, Nicol, R, Purcell, S, Nusbaum, C, Galagan, JE & Dirren, BW 2005, 'The genome sequence of the rice blast fungus Magnaporthe grisea', Nature, vol. 434, no. 7036, pp. 980-986. https://doi.org/10.1038/nature03449
Dean RA, Talbot NJ, Ebbole DJ, Farman ML, Mitchell TK, Orbach MJ et al. The genome sequence of the rice blast fungus Magnaporthe grisea. Nature. 2005 Apr 21;434(7036):980-986. https://doi.org/10.1038/nature03449
Dean, Ralph A. ; Talbot, Nicholas J. ; Ebbole, Daniel J. ; Farman, Mark L. ; Mitchell, Thomas K. ; Orbach, Marc J. ; Thon, Michael ; Kulkarni, Resham ; Xu, Jin Rong ; Pan, Huaqin ; Read, Nick D. ; Lee, Yong Ilwan ; Carbone, Ignazio ; Brown, Doug ; Yeon, Yee Oh ; Donofrio, Nicole ; Jun, Seop Jeong ; Soanes, Darren M. ; Djonovic, Slavica ; Kolomlots, Elena ; Rehmeyer, Cathryn ; Li, Weixl ; Harding, Michael ; Kim, Soonok ; Lebrun, Marc Henri ; Bohnert, Heidi ; Coughlan, Sean ; Butler, Jonathan ; Calvo, Sarah ; Ma, Li Jun ; Nicol, Robert ; Purcell, Seth ; Nusbaum, Chad ; Galagan, James E. ; Dirren, Bruce W. / The genome sequence of the rice blast fungus Magnaporthe grisea. In: Nature. 2005 ; Vol. 434, No. 7036. pp. 980-986.
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