The genome of non-O1 Vibrio cholerae NRT36S demonstrates the presence of pathogenic mechanisms that are distinct from those of O1 Vibrio cholerae

Yuansha Chen; Judith A. Johnson; Gordon D. Pusch; J. Glenn Morris; O. Colin Stine

doi:10.1128/IAI.01317-06

The genome of non-O1 Vibrio cholerae NRT36S demonstrates the presence of pathogenic mechanisms that are distinct from those of O1 Vibrio cholerae

Yuansha Chen, Judith A. Johnson, Gordon D. Pusch, J. Glenn Morris, O. Colin Stine

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Vibrio cholerae NRT36S is a non-cholera toxin-producing, non-O1 strain that causes diarrhea in volunteers. The genome of NRT36S was sequenced to create a draft containing 174 contigs plus the superintegron region. Our analysis of the draft genome revealed several putative toxin genes and colonization factors. Besides confirming the existence of nonagglutinable heat-stable toxin, we also identified the genes for a type three secretion system, a putative exotoxin, two different RTX toxins, and four pilus systems.

Original language	English (US)
Pages (from-to)	2645-2647
Number of pages	3
Journal	Infection and Immunity
Volume	75
Issue number	5
DOIs	https://doi.org/10.1128/IAI.01317-06
State	Published - May 2007
Externally published	Yes

ASJC Scopus subject areas

Immunology

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abstract = "Vibrio cholerae NRT36S is a non-cholera toxin-producing, non-O1 strain that causes diarrhea in volunteers. The genome of NRT36S was sequenced to create a draft containing 174 contigs plus the superintegron region. Our analysis of the draft genome revealed several putative toxin genes and colonization factors. Besides confirming the existence of nonagglutinable heat-stable toxin, we also identified the genes for a type three secretion system, a putative exotoxin, two different RTX toxins, and four pilus systems.",

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AU - Pusch, Gordon D.

AU - Morris, J. Glenn

AU - Stine, O. Colin

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AB - Vibrio cholerae NRT36S is a non-cholera toxin-producing, non-O1 strain that causes diarrhea in volunteers. The genome of NRT36S was sequenced to create a draft containing 174 contigs plus the superintegron region. Our analysis of the draft genome revealed several putative toxin genes and colonization factors. Besides confirming the existence of nonagglutinable heat-stable toxin, we also identified the genes for a type three secretion system, a putative exotoxin, two different RTX toxins, and four pilus systems.

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The genome of non-O1 Vibrio cholerae NRT36S demonstrates the presence of pathogenic mechanisms that are distinct from those of O1 Vibrio cholerae

Abstract

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