The genome of Brugia malayi - All worms are not created equal

Alan Leroy Scott, Elodie Ghedin

Research output: Contribution to journalArticle

Abstract

Filarial nematode parasites, the causative agents of elephantiasis and river blindness, undermine the livelihoods of over one hundred million people in the developing world. Recently, the Filarial Genome Project reported the draft sequence of the ~ 95 Mb genome of the human filarial parasite Brugia malayi - the first parasitic nematode genome to be sequenced. Comparative genome analysis with the prevailing model nematode Caenorhabditis elegans revealed similarities and differences in genome structure and organization that will prove useful as additional nematode genomes are completed. The Brugia genome provides the first opportunity to comprehensively compare the full gene repertoire of a free-living nematode species and one that has evolved as a human pathogen. The Brugia genome also provides an opportunity to gain insight into genetic basis for mutualism, as Brugia, like a majority of filarial species, harbors an endosybiotic bacterium (Wolbachia). The goal of this review is to provide an overview of the results of genomic analysis and how these observations provide new insights into the biology of filarial species.

Original languageEnglish (US)
Pages (from-to)6-11
Number of pages6
JournalParasitology International
Volume58
Issue number1
DOIs
StatePublished - Mar 2009

Fingerprint

Brugia malayi
Genome
Brugia
Parasites
Ocular Onchocerciasis
Elephantiasis
Wolbachia
Symbiosis
Caenorhabditis elegans
Human Genome
Bacteria

Keywords

  • Brugia
  • Caenorhabditis
  • Filarial
  • Genome
  • Nematode

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

The genome of Brugia malayi - All worms are not created equal. / Scott, Alan Leroy; Ghedin, Elodie.

In: Parasitology International, Vol. 58, No. 1, 03.2009, p. 6-11.

Research output: Contribution to journalArticle

@article{6af12f2b3a6342b6acbe66c291cf96db,
title = "The genome of Brugia malayi - All worms are not created equal",
abstract = "Filarial nematode parasites, the causative agents of elephantiasis and river blindness, undermine the livelihoods of over one hundred million people in the developing world. Recently, the Filarial Genome Project reported the draft sequence of the ~ 95 Mb genome of the human filarial parasite Brugia malayi - the first parasitic nematode genome to be sequenced. Comparative genome analysis with the prevailing model nematode Caenorhabditis elegans revealed similarities and differences in genome structure and organization that will prove useful as additional nematode genomes are completed. The Brugia genome provides the first opportunity to comprehensively compare the full gene repertoire of a free-living nematode species and one that has evolved as a human pathogen. The Brugia genome also provides an opportunity to gain insight into genetic basis for mutualism, as Brugia, like a majority of filarial species, harbors an endosybiotic bacterium (Wolbachia). The goal of this review is to provide an overview of the results of genomic analysis and how these observations provide new insights into the biology of filarial species.",
keywords = "Brugia, Caenorhabditis, Filarial, Genome, Nematode",
author = "Scott, {Alan Leroy} and Elodie Ghedin",
year = "2009",
month = "3",
doi = "10.1016/j.parint.2008.09.003",
language = "English (US)",
volume = "58",
pages = "6--11",
journal = "Parasitology International",
issn = "1383-5769",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

TY - JOUR

T1 - The genome of Brugia malayi - All worms are not created equal

AU - Scott, Alan Leroy

AU - Ghedin, Elodie

PY - 2009/3

Y1 - 2009/3

N2 - Filarial nematode parasites, the causative agents of elephantiasis and river blindness, undermine the livelihoods of over one hundred million people in the developing world. Recently, the Filarial Genome Project reported the draft sequence of the ~ 95 Mb genome of the human filarial parasite Brugia malayi - the first parasitic nematode genome to be sequenced. Comparative genome analysis with the prevailing model nematode Caenorhabditis elegans revealed similarities and differences in genome structure and organization that will prove useful as additional nematode genomes are completed. The Brugia genome provides the first opportunity to comprehensively compare the full gene repertoire of a free-living nematode species and one that has evolved as a human pathogen. The Brugia genome also provides an opportunity to gain insight into genetic basis for mutualism, as Brugia, like a majority of filarial species, harbors an endosybiotic bacterium (Wolbachia). The goal of this review is to provide an overview of the results of genomic analysis and how these observations provide new insights into the biology of filarial species.

AB - Filarial nematode parasites, the causative agents of elephantiasis and river blindness, undermine the livelihoods of over one hundred million people in the developing world. Recently, the Filarial Genome Project reported the draft sequence of the ~ 95 Mb genome of the human filarial parasite Brugia malayi - the first parasitic nematode genome to be sequenced. Comparative genome analysis with the prevailing model nematode Caenorhabditis elegans revealed similarities and differences in genome structure and organization that will prove useful as additional nematode genomes are completed. The Brugia genome provides the first opportunity to comprehensively compare the full gene repertoire of a free-living nematode species and one that has evolved as a human pathogen. The Brugia genome also provides an opportunity to gain insight into genetic basis for mutualism, as Brugia, like a majority of filarial species, harbors an endosybiotic bacterium (Wolbachia). The goal of this review is to provide an overview of the results of genomic analysis and how these observations provide new insights into the biology of filarial species.

KW - Brugia

KW - Caenorhabditis

KW - Filarial

KW - Genome

KW - Nematode

UR - http://www.scopus.com/inward/record.url?scp=59249105525&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=59249105525&partnerID=8YFLogxK

U2 - 10.1016/j.parint.2008.09.003

DO - 10.1016/j.parint.2008.09.003

M3 - Article

VL - 58

SP - 6

EP - 11

JO - Parasitology International

JF - Parasitology International

SN - 1383-5769

IS - 1

ER -