The genetics of peroxisome biogenesis

K. A. Sacksteder; S. J. Gould

doi:10.1146/annurev.genet.34.1.623

The genetics of peroxisome biogenesis

K. A. Sacksteder, S. J. Gould

School of Medicine

Research output: Contribution to journal › Review article › peer-review

96 Scopus citations

Abstract

The segregation of metabolic functions within discrete organelles is a hallmark of eukaryotic cells. These compartments allow for the concentration of related metabolic functions, the separation of competing metabolic functions, and the formation of unique chemical microenvironments. However, such organization is not spontaneous and requires an array of genes that are dedicated to the assembly and maintenance of these structures. In this review we focus on the genetics of peroxisome biogenesis and on how defects in this process cause human disease.

Original language	English (US)
Pages (from-to)	623-652
Number of pages	30
Journal	Annual review of genetics
Volume	34
DOIs	https://doi.org/10.1146/annurev.genet.34.1.623
State	Published - 2000

Keywords

Organelle assembly
Peroxins
Protein import
Zellweger syndrome
pex genes

ASJC Scopus subject areas

Genetics

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10.1146/annurev.genet.34.1.623

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AB - The segregation of metabolic functions within discrete organelles is a hallmark of eukaryotic cells. These compartments allow for the concentration of related metabolic functions, the separation of competing metabolic functions, and the formation of unique chemical microenvironments. However, such organization is not spontaneous and requires an array of genes that are dedicated to the assembly and maintenance of these structures. In this review we focus on the genetics of peroxisome biogenesis and on how defects in this process cause human disease.

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KW - Peroxins

KW - Protein import

KW - Zellweger syndrome

KW - pex genes

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The genetics of peroxisome biogenesis

Abstract

Keywords

ASJC Scopus subject areas

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