The genetics of olfaction

Irene C. Griff, Randall R. Reed

Research output: Contribution to journalArticlepeer-review


Our understanding of olfaction has progressed rapidly in recent years as a result of the molecular genetic approaches being used to study this sensory system in a variety of model organisms. Considerable success has been achieved in identifying proteins of the mammalian signaling system that are analogous to those present in other sensory systems. More recently, genetic selection of mutations that cause defects in olfactory function in Drosophila melanogaster and Caenorhabditis elegans has led to the identification of additional proteins that play a role in the detection of odorants. The application of genetic, electrophysiological, and molecular analyses to olfactory function in mammals is also shedding light on the mechanisms that account for sensitivity and specificity in this system. (This review also appears in Current Opinion in Neurobiology 1995, 5:456-460.).

Original languageEnglish (US)
Pages (from-to)657-661
Number of pages5
JournalCurrent Opinion in Genetics and Development
Issue number5
StatePublished - Oct 1995
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology


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