The genetics of obsessive-compulsive disorder and Tourette's syndrome: What are the common factors?

Research output: Contribution to journalArticle

Abstract

Genetic discovery in obsessive-compulsive disorder and Tourette's syndrome has made significant progress in the past decade. The two disorders are phenomenologically, epidemiologically, and probably pathophysiologically related; however, as with most neuropsychiatric disorders, gene discovery has been challenging. Genetic epidemiology studies support the existence of susceptibility genes in both disorders, and more extensive genome-wide studies are under way. Gene pathways involving neurotransmitter (serotonin, dopamine, glutamate) and neurodevelopment (synaptic, homeobox) domains have been examined, but more complex genetic mechanisms remain largely unexplored. This review addresses the current state of genetic research in obsessive-compulsive disorder and Tourette's syndrome, emphasizing commonalities between the disorders. Questions on common genetic substrates, the use of endophenotypes, and the utility of genetic data to inform pharmacologic treatment are also addressed.

Original languageEnglish (US)
Pages (from-to)162-166
Number of pages5
JournalCurrent Psychiatry Reports
Volume11
Issue number2
DOIs
StatePublished - 2009

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Tourette Syndrome
Obsessive-Compulsive Disorder
Endophenotypes
Genetic Research
Molecular Epidemiology
Homeobox Genes
Genetic Association Studies
Genes
Neurotransmitter Agents
Glutamic Acid
Dopamine
Serotonin
Genome

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

The genetics of obsessive-compulsive disorder and Tourette's syndrome : What are the common factors? / Grados, Marco.

In: Current Psychiatry Reports, Vol. 11, No. 2, 2009, p. 162-166.

Research output: Contribution to journalArticle

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