Abstract
Genetic discovery in obsessive-compulsive disorder and Tourette's syndrome has made significant progress in the past decade. The two disorders are phenomenologically, epidemiologically, and probably pathophysiologically related; however, as with most neuropsychiatric disorders, gene discovery has been challenging. Genetic epidemiology studies support the existence of susceptibility genes in both disorders, and more extensive genome-wide studies are under way. Gene pathways involving neurotransmitter (serotonin, dopamine, glutamate) and neurodevelopment (synaptic, homeobox) domains have been examined, but more complex genetic mechanisms remain largely unexplored. This review addresses the current state of genetic research in obsessive-compulsive disorder and Tourette's syndrome, emphasizing commonalities between the disorders. Questions on common genetic substrates, the use of endophenotypes, and the utility of genetic data to inform pharmacologic treatment are also addressed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 162-166 |
| Number of pages | 5 |
| Journal | Current Psychiatry Reports |
| Volume | 11 |
| Issue number | 2 |
| DOIs | |
| State | Published - 2009 |
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ASJC Scopus subject areas
- Psychiatry and Mental health
Cite this
The genetics of obsessive-compulsive disorder and Tourette's syndrome : What are the common factors? / Grados, Marco.
In: Current Psychiatry Reports, Vol. 11, No. 2, 2009, p. 162-166.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The genetics of obsessive-compulsive disorder and Tourette's syndrome
T2 - What are the common factors?
AU - Grados, Marco
PY - 2009
Y1 - 2009
N2 - Genetic discovery in obsessive-compulsive disorder and Tourette's syndrome has made significant progress in the past decade. The two disorders are phenomenologically, epidemiologically, and probably pathophysiologically related; however, as with most neuropsychiatric disorders, gene discovery has been challenging. Genetic epidemiology studies support the existence of susceptibility genes in both disorders, and more extensive genome-wide studies are under way. Gene pathways involving neurotransmitter (serotonin, dopamine, glutamate) and neurodevelopment (synaptic, homeobox) domains have been examined, but more complex genetic mechanisms remain largely unexplored. This review addresses the current state of genetic research in obsessive-compulsive disorder and Tourette's syndrome, emphasizing commonalities between the disorders. Questions on common genetic substrates, the use of endophenotypes, and the utility of genetic data to inform pharmacologic treatment are also addressed.
AB - Genetic discovery in obsessive-compulsive disorder and Tourette's syndrome has made significant progress in the past decade. The two disorders are phenomenologically, epidemiologically, and probably pathophysiologically related; however, as with most neuropsychiatric disorders, gene discovery has been challenging. Genetic epidemiology studies support the existence of susceptibility genes in both disorders, and more extensive genome-wide studies are under way. Gene pathways involving neurotransmitter (serotonin, dopamine, glutamate) and neurodevelopment (synaptic, homeobox) domains have been examined, but more complex genetic mechanisms remain largely unexplored. This review addresses the current state of genetic research in obsessive-compulsive disorder and Tourette's syndrome, emphasizing commonalities between the disorders. Questions on common genetic substrates, the use of endophenotypes, and the utility of genetic data to inform pharmacologic treatment are also addressed.
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UR - http://www.scopus.com/inward/citedby.url?scp=63549133694&partnerID=8YFLogxK
U2 - 10.1007/s11920-009-0025-x
DO - 10.1007/s11920-009-0025-x
M3 - Article
C2 - 19302771
AN - SCOPUS:63549133694
VL - 11
SP - 162
EP - 166
JO - Current Psychiatry Reports
JF - Current Psychiatry Reports
SN - 1523-3812
IS - 2
ER -