TY - JOUR
T1 - The genetics of Mexico recapitulates Native American substructure and affects biomedical traits
AU - Moreno-Estrada, Andrés
AU - Gignoux, Christopher R.
AU - Fernández-López, Juan Carlos
AU - Zakharia, Fouad
AU - Sikora, Martin
AU - Contreras, Alejandra V.
AU - Acuña-Alonzo, Victor
AU - Sandoval, Karla
AU - Eng, Celeste
AU - Romero-Hidalgo, Sandra
AU - Ortiz-Tello, Patricia
AU - Robles, Victoria
AU - Kenny, Eimear E.
AU - Nuño-Arana, Ismael
AU - Barquera-Lozano, Rodrigo
AU - Macín-Pérez, Gastón
AU - Granados-Arriola, Julio
AU - Huntsman, Scott
AU - Galanter, Joshua M.
AU - Via, Marc
AU - Ford, Jean G.
AU - Chapela, Rocío
AU - Rodriguez-Cintron, William
AU - Rodríguez-Santana, Jose R.
AU - Romieu, Isabelle
AU - Sienra-Monge, Juan José
AU - Del Rio Navarro, Blanca
AU - London, Stephanie J.
AU - Ruiz-Linares, Andrés
AU - Garcia-Herrera, Rodrigo
AU - Estrada, Karol
AU - Hidalgo-Miranda, Alfredo
AU - Jimenez-Sanchez, Gerardo
AU - Carnevale, Alessandra
AU - Soberón, Xavier
AU - Canizales-Quinteros, Samuel
AU - Rangel-Villalobos, Héctor
AU - Silva-Zolezzi, Irma
AU - Burchard, Esteban Gonzalez
AU - Bustamante, Carlos D.
PY - 2014
Y1 - 2014
N2 - Mexico harbors great cultural and ethnic diversity, yet fine-scale patterns of human genome-wide variation from this region remain largely uncharacterized. We studied genomic variation within Mexico from over 1000 individuals representing 20 indigenous and 11 mestizo populations. We found striking genetic stratification among indigenous populations within Mexico at varying degrees of geographic isolation. Some groups were as differentiated as Europeans are from East Asians. Pre-Columbian genetic substructure is recapitulated in the indigenous ancestry of admixed mestizo individuals across the country. Furthermore, two independently phenotyped cohorts of Mexicans and Mexican Americans showed a significant association between subcontinental ancestry and lung function. Thus, accounting for fine-scale ancestry patterns is critical for medical and population genetic studies within Mexico, in Mexican-descent populations, and likely in many other populations worldwide.
AB - Mexico harbors great cultural and ethnic diversity, yet fine-scale patterns of human genome-wide variation from this region remain largely uncharacterized. We studied genomic variation within Mexico from over 1000 individuals representing 20 indigenous and 11 mestizo populations. We found striking genetic stratification among indigenous populations within Mexico at varying degrees of geographic isolation. Some groups were as differentiated as Europeans are from East Asians. Pre-Columbian genetic substructure is recapitulated in the indigenous ancestry of admixed mestizo individuals across the country. Furthermore, two independently phenotyped cohorts of Mexicans and Mexican Americans showed a significant association between subcontinental ancestry and lung function. Thus, accounting for fine-scale ancestry patterns is critical for medical and population genetic studies within Mexico, in Mexican-descent populations, and likely in many other populations worldwide.
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U2 - 10.1126/science.1251688
DO - 10.1126/science.1251688
M3 - Article
C2 - 24926019
AN - SCOPUS:84902603117
SN - 0036-8075
VL - 344
SP - 1280
EP - 1285
JO - Science
JF - Science
IS - 6189
ER -