Steady-state level of liver 3′,5′-cyclic monophosphate, cAMP, has been shown to be under genetic control linked to the mouse H-2 complex. Liver cAMP levels are associated with H-2 haplotype in fully segregating crosses of strains C3H and C57BL/10. In crosses involving strain A, other loci have an effect that swamps that of H-2. Results with H-2 recombinants indicate that liver cAMP levels are affected by more than one H-2-linked locus.
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