The genetic basis of renal epithelial tumors: Advances in research and its impact on prognosis and therapy

John L. Phillips, Christian P. Pavlovich, McClellan Walther, Thomas Ried, W. Marston Linehan

Research output: Contribution to journalReview articlepeer-review

Abstract

The genetics of renal cell carcinoma continues to elucidate the pathways of kidney tumorigenesis. The relationship between the VHL gene and clear cell carcinoma, MET and papillary carcinoma, and the families of genes that they regulate, continues to be unraveled. New hereditary kidney cancer syndromes, like familial oncocytoma and the Birt-Hogg-Dubé syndrome, have been identified and the search for the genes that cause them is under way. Researching the genetics of these disorders is essential for an understanding of sporadic kidney cancer genetics. This chapter will review the current knowledge of the hereditary kidney cancer syndromes, the genes that cause them, new advances in genetic research and techniques, and how this information impacts upon diagnostic, prognostic, and therapeutic methods of the future.

Original languageEnglish (US)
Pages (from-to)463-469
Number of pages7
JournalCurrent opinion in urology
Volume11
Issue number5
DOIs
StatePublished - Sep 5 2001
Externally publishedYes

ASJC Scopus subject areas

  • Urology

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