Abstract
The recognition of hereditary forms of renal cancer and the development of high-throughput genetic analysis have led to the identification of genes responsible for familial renal epithelial tumors of differing histologies and cytogenetic features. Some of these genes (VHL) are known to have an important role in sporadic renal neoplasia. This article describes the various epithelial renal tumors most commonly encountered by the urologist, the molecular and cytogenetic distinctions between them, and the hereditary syndromes that predispose to these tumors. Consideration of these syndromes is important for proper treatment when one encounters patients with multiple renal tumors, tumors at an early age of onset, or patients with a positive family history of renal cell carcinoma.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 437-454 |
| Number of pages | 18 |
| Journal | Urologic Clinics of North America |
| Volume | 30 |
| Issue number | 3 |
| DOIs | |
| State | Published - Aug 2003 |
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ASJC Scopus subject areas
- Urology
Cite this
The genetic basis of renal cell carcinoma. / Pavlovich, Christian; Schmidt, Laura S.; Phillips, John L.
In: Urologic Clinics of North America, Vol. 30, No. 3, 08.2003, p. 437-454.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The genetic basis of renal cell carcinoma
AU - Pavlovich, Christian
AU - Schmidt, Laura S.
AU - Phillips, John L.
PY - 2003/8
Y1 - 2003/8
N2 - The recognition of hereditary forms of renal cancer and the development of high-throughput genetic analysis have led to the identification of genes responsible for familial renal epithelial tumors of differing histologies and cytogenetic features. Some of these genes (VHL) are known to have an important role in sporadic renal neoplasia. This article describes the various epithelial renal tumors most commonly encountered by the urologist, the molecular and cytogenetic distinctions between them, and the hereditary syndromes that predispose to these tumors. Consideration of these syndromes is important for proper treatment when one encounters patients with multiple renal tumors, tumors at an early age of onset, or patients with a positive family history of renal cell carcinoma.
AB - The recognition of hereditary forms of renal cancer and the development of high-throughput genetic analysis have led to the identification of genes responsible for familial renal epithelial tumors of differing histologies and cytogenetic features. Some of these genes (VHL) are known to have an important role in sporadic renal neoplasia. This article describes the various epithelial renal tumors most commonly encountered by the urologist, the molecular and cytogenetic distinctions between them, and the hereditary syndromes that predispose to these tumors. Consideration of these syndromes is important for proper treatment when one encounters patients with multiple renal tumors, tumors at an early age of onset, or patients with a positive family history of renal cell carcinoma.
UR - http://www.scopus.com/inward/record.url?scp=0042320503&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0042320503&partnerID=8YFLogxK
U2 - 10.1016/S0094-0143(03)00023-5
DO - 10.1016/S0094-0143(03)00023-5
M3 - Article
C2 - 12953747
AN - SCOPUS:0042320503
VL - 30
SP - 437
EP - 454
JO - Urologic Clinics of North America
JF - Urologic Clinics of North America
SN - 0094-0143
IS - 3
ER -