The gene encoding interleukin-13: A susceptibility locus for asthma and related traits

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Abstract

Asthma is a complex inflammatory disorder controlled by both genetic and environmental influences. Multiple genetic analyses have identified the T helper type 2 (Th2) cytokine gene cluster on chromosome 5q as a susceptibility locus for asthma. Recently, the Th2 cytokine interleukin-13 has been shown to be a critical mediator of the asthma phenotype in murine models. In this commentary we discuss several recent studies that have identified polymorphisms in the gene encoding interleukin-13. The consistent genetic associations of interleukin-13 with asthma and related traits across diverse ethnic populations in these studies provides strong support for the candidacy of this cytokine as a susceptibility locus for asthma and atopy on chromosome 5q31.

Original languageEnglish (US)
Pages (from-to)19-23
Number of pages5
JournalRespiratory research
Volume1
Issue number1
DOIs
StatePublished - 2000

Keywords

  • Asthma
  • Atopy
  • Genetics
  • Interleukin-13
  • Interleukin-4 receptor

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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