The functional properties of the G protein-coupled receptor melanopsin in intrinsically photosensitive retinal ganglion cells: Novel photoreceptors controlling diverse visual functions

Alan C. Rupp, Samer Hattar

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Only slightly over a decade ago, the rods and cones in the outer retina were thought to be the exclusive photoreceptors in mammals. Since then, the discovery of an additional photopigment melanopsin (a G protein-coupled receptor, GPCR) expressed in a small subset of intrinsically photosensitive retinal ganglion cells (ipRGCs) has expanded upon the conventional view of light detection and information flow in the retina. In this chapter, we will highlight our current understanding of the structure and function of melanopsin, the cell biology and physiology of ipRGCs, how ipRGCs are integrated into the retinal circuitry, and the role of ipRGCs in visual behaviors.

Original languageEnglish (US)
Title of host publicationG Protein Signaling Mechanisms in the Retina
PublisherSpringer New York
Pages173-195
Number of pages23
ISBN (Electronic)9781493912186
ISBN (Print)9781493912179
DOIs
StatePublished - Jan 1 2014

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)

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