The functional neuroanatomy of tourette's syndrome: An FDG-PET Study. II: Relationships between regional cerebral metabolism and associated behavioral and cognitive features of the Illness

Allen R. Braun, Christopher Randolph, Brigitte Stoetter, Erich Mohr, Christine Cox, Katalin Vladar, Roy Sexton, Richard E. Carson, Peter Herscovitch, Thomas N. Chase

Research output: Contribution to journalArticlepeer-review

Abstract

We analyzed F-18 fluoro-deoxyglucose PET scans earned out in 18 drug-free patients with Tourette’s syndrome (TS) in order to evaluate relationships between cerebral metabolism and complex cognitive and behavioral features commonly associated with this disorder. These features (obsessions and compulsions, impulsivity, coprolalia, self-injurious behavior, echophenomena, depression, and measures of attentional and visuospatial dysfunction) were associated with significant increases in metabolic activity in the orbitofrontal cortices. Similar increases, although less robust, were observed in the putamen and, in the case of attentional and visuospatial measures, in the inferior portions of the insula. On the other hand, behavioral and cognitive features were not associated with metabolic rates in other subcortical (midbrain, ventral striatum), paralimbic (parahippocampal gyrus), or sensorimotor regions (supplementary motor area, lateral premotor or Rolandic cortices), in which metabolism had, in some cases more robustly, distinguished these TS patients from controls (Braun et al., 1993). These results suggest that a subset of regions in which metabolic activity appears to be associated with the diagnosis of TS per se, may be explicitly associated with the emergence of complex behavioral and cognitive features of the illness. This is most conspicuous in the orbitofrontal cortices, and it is consistent with the observation that these features resemble the elements of a behavioral syndrome typically seen in patients with lesions of the orbitofrontal cortex. I Neuropsychopharmacology.

Original languageEnglish (US)
Pages (from-to)151-168
Number of pages18
JournalNeuropsychopharmacology
Volume13
Issue number2
DOIs
StatePublished - Oct 1995
Externally publishedYes

Keywords

  • Attention
  • Basal ganglia
  • Coprolalia
  • Depression
  • Echophenomena
  • FDG
  • Impulsivity
  • Insula
  • Obsessive-compulsive disorder
  • Orbitofrontal cortex
  • Positron emission tomography
  • Self-injurious behavior
  • Tourette's (Tourette) syndrome
  • Visuospatial

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health

Fingerprint

Dive into the research topics of 'The functional neuroanatomy of tourette's syndrome: An FDG-PET Study. II: Relationships between regional cerebral metabolism and associated behavioral and cognitive features of the Illness'. Together they form a unique fingerprint.

Cite this