TY - JOUR
T1 - The frequency of lupus anticoagulant in systemic lupus erythematosus. A study of sixty consecutive patients by activated partial thromboplastin time, Russell viper venom time, and anticardiolipin antibody level
AU - Petri, M.
AU - Rheinschmidt, M.
AU - Whiting-O'Keefe, Q.
AU - Hellmann, D.
AU - Corash, L.
PY - 1987
Y1 - 1987
N2 - Recent reviews have suggested a higher frequency of the lupus anticoagulant or related antiphospholipid antibodies in patients with systemic lupus erythematosus (21% to 65%) than was found in earlier studies (6% to 18%). In our study of 60 consecutive patients, we found the frequency of the lupus anticoagulant by Russell viper venom time was 6.7% (95% confidence interval, 16.2 to 1.8) and by anticardiolipin antibody assay was 25% (95% Cl, 37.0 to 15.7), compared with 0% (p=not significant) and 2.5% (p=0.002), respectively, in the normal control population. The Russell viper venom time (P=0.0001 by t-test) and anticardiolipin antibody levels (p=0.01) were significantly associated with presumed thrombotic events (stroke, deep venous thrombosis, and digital gangrene). No association with miscarriage or pulmonary hypertension was detected. The Russell viper venom time was more specific than the anticardiolipin antibody level in the prediction of past presumed thrombotic events, miscarriage, or pulmonary hypertension (100% compared with 84%, p=0.01).
AB - Recent reviews have suggested a higher frequency of the lupus anticoagulant or related antiphospholipid antibodies in patients with systemic lupus erythematosus (21% to 65%) than was found in earlier studies (6% to 18%). In our study of 60 consecutive patients, we found the frequency of the lupus anticoagulant by Russell viper venom time was 6.7% (95% confidence interval, 16.2 to 1.8) and by anticardiolipin antibody assay was 25% (95% Cl, 37.0 to 15.7), compared with 0% (p=not significant) and 2.5% (p=0.002), respectively, in the normal control population. The Russell viper venom time (P=0.0001 by t-test) and anticardiolipin antibody levels (p=0.01) were significantly associated with presumed thrombotic events (stroke, deep venous thrombosis, and digital gangrene). No association with miscarriage or pulmonary hypertension was detected. The Russell viper venom time was more specific than the anticardiolipin antibody level in the prediction of past presumed thrombotic events, miscarriage, or pulmonary hypertension (100% compared with 84%, p=0.01).
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U2 - 10.7326/0003-4819-106-4-524
DO - 10.7326/0003-4819-106-4-524
M3 - Article
C2 - 3103510
AN - SCOPUS:0023220110
SN - 0003-4819
VL - 106
SP - 524
EP - 531
JO - Annals of internal medicine
JF - Annals of internal medicine
IS - 4
ER -