The Frailty Syndrome: Definition and Natural History

Research output: Contribution to journalReview articlepeer-review

636 Scopus citations


This article reviews the current state of knowledge regarding the epidemiology of frailty by focusing on 6 specific areas: (1) clinical definitions of frailty, (2) evidence of frailty as a medical syndrome, (3) prevalence and incidence of frailty by age, gender, race, and ethnicity, (4) transitions between discrete frailty states, (5) natural history of manifestations of frailty criteria, and (6) behavior modifications as precursors to the development of clinical frailty.

Original languageEnglish (US)
Pages (from-to)1-15
Number of pages15
JournalClinics in geriatric medicine
Issue number1
StatePublished - Feb 2011


  • Clinical phenotype
  • Frailty
  • Hazard ratio
  • Latent class analysis

ASJC Scopus subject areas

  • Geriatrics and Gerontology


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