TY - JOUR
T1 - The follicular outcome after standard gonadotropin stimulation is associated with ERα and ERβ genotypes
AU - Lazaros, Leandros
AU - Pamporaki, Christina
AU - Vlahos, Nikolaos
AU - Takenaka, Atsushi
AU - Kitsou, Chrysoula
AU - Kosmas, Ioannis
AU - Sofikitis, Nikolaos
AU - Stefos, Theodoros
AU - Zikopoulos, Konstantinos
AU - Hatzi, Elissavet
AU - Georgiou, Ioannis
N1 - Publisher Copyright:
© 2014, Springer Science+Business Media New York.
PY - 2014/11/21
Y1 - 2014/11/21
N2 - The aim is to study the association of estrogen receptor α (ERα) and estrogen receptor β (ERβ) gene polymorphisms and diplotypes with ovarian response to follicle-stimulating hormone (FSH) stimulation and the hormone levels [FSH, luteinizing hormone (LH), E2] at the third day of the menstrual cycle. Three hundred women undergoing medically assisted reproduction and 300 women with at least one spontaneous pregnancy participated in the study. ERα PvuII and XbaI polymorphisms as well as ERβAluI polymorphism were genotyped. The FSH, LH, and E2 levels were determined at the third day of the menstrual cycle, while the follicular size, the follicle, and oocyte numbers were recorded during oocyte retrieval. PvuII CC, XbaI GG, and AluI GG women were characterized by increased amounts of large follicles compared to PvuII TT, XbaI AA, and AluI AA women (p = 0.045, 0.01, and 0.033, respectively). The PvuII CC/XbaI GG diplotype was also significantly associated with higher large follicle numbers compared to the PvuII TT/XbaI AA diplotype (p = 0.024). However, no associations were observed between ER gene polymorphisms and the hormonal profile, the follicle/oocyte numbers, and the pregnancy rates. ERα and ERβ genetic variants were associated with ovarian response to standard gonadotropin stimulation of women undergoing in-vitro fertilization affecting mainly the follicular growth.
AB - The aim is to study the association of estrogen receptor α (ERα) and estrogen receptor β (ERβ) gene polymorphisms and diplotypes with ovarian response to follicle-stimulating hormone (FSH) stimulation and the hormone levels [FSH, luteinizing hormone (LH), E2] at the third day of the menstrual cycle. Three hundred women undergoing medically assisted reproduction and 300 women with at least one spontaneous pregnancy participated in the study. ERα PvuII and XbaI polymorphisms as well as ERβAluI polymorphism were genotyped. The FSH, LH, and E2 levels were determined at the third day of the menstrual cycle, while the follicular size, the follicle, and oocyte numbers were recorded during oocyte retrieval. PvuII CC, XbaI GG, and AluI GG women were characterized by increased amounts of large follicles compared to PvuII TT, XbaI AA, and AluI AA women (p = 0.045, 0.01, and 0.033, respectively). The PvuII CC/XbaI GG diplotype was also significantly associated with higher large follicle numbers compared to the PvuII TT/XbaI AA diplotype (p = 0.024). However, no associations were observed between ER gene polymorphisms and the hormonal profile, the follicle/oocyte numbers, and the pregnancy rates. ERα and ERβ genetic variants were associated with ovarian response to standard gonadotropin stimulation of women undergoing in-vitro fertilization affecting mainly the follicular growth.
KW - Assisted reproduction
KW - Estrogen receptor gene polymorphism
KW - Follicles
KW - IVF
KW - Oocytes
KW - Ovarian stimulation
KW - RFLP
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U2 - 10.1007/s12020-014-0249-3
DO - 10.1007/s12020-014-0249-3
M3 - Article
C2 - 24705910
AN - SCOPUS:84911967382
SN - 1355-008X
VL - 47
SP - 930
EP - 935
JO - Endocrine
JF - Endocrine
IS - 3
ER -