The fission yeast cdc18+ gene product couples S phase to START and mitosis

Thomas J. Kelly, G. Steven Martin, Susan L. Forsburg, Robert J. Stephen, Alicia Russo, Paul Nurse

Research output: Contribution to journalArticlepeer-review

Abstract

Commitment to the cell cycle in fission yeast requires the function of the cdc10+ transcriptional activator at START. The product of the cdc18+ gene is a major downstream target of cdc10+, and transcription of cdc18+ is activated by cdc10+ during passage through START. The cdc18+ function is required for entry into S phase. In addition, the product of the cdc18+ gene is part of the checkpoint control that prevents mitosis from occurring until S phase is completed. Thus, cdc18+ plays a key role in coupling S phase to START and mitosis.

Original languageEnglish (US)
Pages (from-to)371-382
Number of pages12
JournalCell
Volume74
Issue number2
DOIs
StatePublished - Jul 30 1993

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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