The fission yeast cdc18+ gene product couples S phase to START and mitosis

Thomas J. Kelly; G. Steven Martin; Susan L. Forsburg; Robert J. Stephen; Alicia Russo; Paul Nurse

doi:10.1016/0092-8674(93)90427-R

The fission yeast cdc18⁺ gene product couples S phase to START and mitosis

Thomas J. Kelly, G. Steven Martin, Susan L. Forsburg, Robert J. Stephen, Alicia Russo, Paul Nurse

School of Medicine

Research output: Contribution to journal › Article

Abstract

Commitment to the cell cycle in fission yeast requires the function of the cdc10⁺ transcriptional activator at START. The product of the cdc18⁺ gene is a major downstream target of cdc10⁺, and transcription of cdc18⁺ is activated by cdc10⁺ during passage through START. The cdc18⁺ function is required for entry into S phase. In addition, the product of the cdc18⁺ gene is part of the checkpoint control that prevents mitosis from occurring until S phase is completed. Thus, cdc18⁺ plays a key role in coupling S phase to START and mitosis.

Original language	English (US)
Pages (from-to)	371-382
Number of pages	12
Journal	Cell
Volume	74
Issue number	2
DOIs	https://doi.org/10.1016/0092-8674(93)90427-R
State	Published - Jul 30 1993

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ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Cite this

Kelly, T. J., Martin, G. S., Forsburg, S. L., Stephen, R. J., Russo, A., & Nurse, P. (1993). The fission yeast cdc18⁺ gene product couples S phase to START and mitosis. Cell, 74(2), 371-382. https://doi.org/10.1016/0092-8674(93)90427-R

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10.1016/0092-8674(93)90427-R