The first potassium channel toxin from the venom of the Iranian scorpion Odonthobuthus doriae

Yousra Abdel-Mottaleb, Elke Clynen, Amir Jalali, Frank Bosmans, Hossein Vatanpour, Liliane Schoofs, Jan Tytgat

Research output: Contribution to journalArticlepeer-review

Abstract

The very first member of K+ channels toxins from the venom of the Iranian scorpion Odonthobuthus doriae (OdK1) was purified, sequenced and characterized physiologically. OdK1 has 29 amino acids, six conserved cysteines and a pI value of 4.95. Based on multiple sequence alignments, OdK1 was classified as α-KTx 8.5. The pharmacological effects of OdK1 were studied on six different cloned K+ channels (vertebrate Kv1.1-Kv1.5 and Shaker IR) expressed in Xenopus laevis oocytes. Interestingly, OdK1 selectively inhibited the currents through Kv1.2 channels with an IC50 value of 183 ± 3 nM but did not affect any of the other channels.

Original languageEnglish (US)
Pages (from-to)6254-6258
Number of pages5
JournalFEBS Letters
Volume580
Issue number26
DOIs
StatePublished - Nov 13 2006

Keywords

  • Odonthubuthus doriae
  • Voltage-gated K channels
  • α-KTx 8.5

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Fingerprint

Dive into the research topics of 'The first potassium channel toxin from the venom of the Iranian scorpion Odonthobuthus doriae'. Together they form a unique fingerprint.

Cite this