The Final Touches Make Perfect the Peptide-MHC Class I Repertoire

Gianna Elena Hammer; Takayuki Kanaseki; Nilabh Shastri

doi:10.1016/j.immuni.2007.04.003

The Final Touches Make Perfect the Peptide-MHC Class I Repertoire

Gianna Elena Hammer, Takayuki Kanaseki, Nilabh Shastri

Research output: Contribution to journal › Review article › peer-review

77 Scopus citations

Abstract

Major histocompatibility complex (MHC) class I molecules present short, perfectly cleaved peptides on the cell surface for immune surveillance by CD8⁺ T cells. The pathway for generating these peptides begins in the cytoplasm, and the peptide-MHC I (pMHC I) repertoire is finalized in the endoplasmic reticulum. Recent studies show that the peptides for MHC I are customized by the ER aminopeptidase associated with antigen processing and by dynamic interactions within the MHC peptide-loading complex. Failure to customize the pMHC I repertoire has profound immunological consequences.

Original language	English (US)
Pages (from-to)	397-406
Number of pages	10
Journal	Immunity
Volume	26
Issue number	4
DOIs	https://doi.org/10.1016/j.immuni.2007.04.003
State	Published - Apr 27 2007
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

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10.1016/j.immuni.2007.04.003

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abstract = "Major histocompatibility complex (MHC) class I molecules present short, perfectly cleaved peptides on the cell surface for immune surveillance by CD8+ T cells. The pathway for generating these peptides begins in the cytoplasm, and the peptide-MHC I (pMHC I) repertoire is finalized in the endoplasmic reticulum. Recent studies show that the peptides for MHC I are customized by the ER aminopeptidase associated with antigen processing and by dynamic interactions within the MHC peptide-loading complex. Failure to customize the pMHC I repertoire has profound immunological consequences.",

author = "Hammer, {Gianna Elena} and Takayuki Kanaseki and Nilabh Shastri",

note = "Funding Information: We are grateful to our colleagues, past and present, who contributed methods, observations, and ideas discussed here. We thank N. Blanchard and N. Nagaragan for thoughtful comments on the manuscript. The unpublished data we discussed here was made possible by L. Van Kaer. Research in this laboratory is supported by grants from the National Institutes of Health to N.S.",

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AU - Hammer, Gianna Elena

AU - Kanaseki, Takayuki

AU - Shastri, Nilabh

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N2 - Major histocompatibility complex (MHC) class I molecules present short, perfectly cleaved peptides on the cell surface for immune surveillance by CD8+ T cells. The pathway for generating these peptides begins in the cytoplasm, and the peptide-MHC I (pMHC I) repertoire is finalized in the endoplasmic reticulum. Recent studies show that the peptides for MHC I are customized by the ER aminopeptidase associated with antigen processing and by dynamic interactions within the MHC peptide-loading complex. Failure to customize the pMHC I repertoire has profound immunological consequences.

AB - Major histocompatibility complex (MHC) class I molecules present short, perfectly cleaved peptides on the cell surface for immune surveillance by CD8+ T cells. The pathway for generating these peptides begins in the cytoplasm, and the peptide-MHC I (pMHC I) repertoire is finalized in the endoplasmic reticulum. Recent studies show that the peptides for MHC I are customized by the ER aminopeptidase associated with antigen processing and by dynamic interactions within the MHC peptide-loading complex. Failure to customize the pMHC I repertoire has profound immunological consequences.

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The Final Touches Make Perfect the Peptide-MHC Class I Repertoire

Abstract

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