The Final Touches Make Perfect the Peptide-MHC Class I Repertoire

Gianna Elena Hammer, Takayuki Kanaseki, Nilabh Shastri

Research output: Contribution to journalReview articlepeer-review

Abstract

Major histocompatibility complex (MHC) class I molecules present short, perfectly cleaved peptides on the cell surface for immune surveillance by CD8+ T cells. The pathway for generating these peptides begins in the cytoplasm, and the peptide-MHC I (pMHC I) repertoire is finalized in the endoplasmic reticulum. Recent studies show that the peptides for MHC I are customized by the ER aminopeptidase associated with antigen processing and by dynamic interactions within the MHC peptide-loading complex. Failure to customize the pMHC I repertoire has profound immunological consequences.

Original languageEnglish (US)
Pages (from-to)397-406
Number of pages10
JournalImmunity
Volume26
Issue number4
DOIs
StatePublished - Apr 27 2007
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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