TY - JOUR
T1 - The fetal trimethadione syndrome
AU - Lietman, Paul S.
AU - Zackai, Elaine H.
AU - Mellman, William J.
AU - Neiderer, Bettina
AU - Hanson, James W.
N1 - Funding Information:
Supported by the following grants from the United States Public Health Service. HD 00588, HD 04861, GM 20138, and RR 00240. *Reprint address: Children's Hospital of Philadelphia, 34th & Civic Center Blvd., Philadelphia, Pa. 19104.
PY - 1975/8
Y1 - 1975/8
N2 - Three families are described in which each of the mothers took trimethadione during pregnancy. From a comparison of siblings in each family and of others exposed to trimethadione in utero, a specific phenotype is delineated. Features included in the fetal trimethadione syndrome are developmental delay, speech difficulty, V-shaped eyebrows, epicanthus, low-set ears with anteriorly folded helix, palatal anomaly, and irregular teeth. Additional anomalies in some of the patients include intrauterine growth retardation, short stature, microcephaly, cardiac anomaly, ocular anomaly, hypospadias, inguinal hernia, and simian creases.
AB - Three families are described in which each of the mothers took trimethadione during pregnancy. From a comparison of siblings in each family and of others exposed to trimethadione in utero, a specific phenotype is delineated. Features included in the fetal trimethadione syndrome are developmental delay, speech difficulty, V-shaped eyebrows, epicanthus, low-set ears with anteriorly folded helix, palatal anomaly, and irregular teeth. Additional anomalies in some of the patients include intrauterine growth retardation, short stature, microcephaly, cardiac anomaly, ocular anomaly, hypospadias, inguinal hernia, and simian creases.
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U2 - 10.1016/S0022-3476(75)80603-2
DO - 10.1016/S0022-3476(75)80603-2
M3 - Article
C2 - 50427
AN - SCOPUS:0016742469
VL - 87
SP - 280
EP - 284
JO - Journal of Pediatrics
JF - Journal of Pediatrics
SN - 0022-3476
IS - 2
ER -