The FcγRIIIA-158F allele is a risk factor for systemic lupus erythematosus

Harry R. Koene, Marion Kleijer, Anton J.G. Swaak, Kathleen E. Sullivan, Marc Bijl, Michelle A. Petri, Cees G.M. Kallenberg, Dirk Roos, Albert E.G.K. Von Dem Borne, Masja De Haas

Research output: Contribution to journalArticlepeer-review

114 Scopus citations


Objective. To study whether the FcγRIIIA-158V/F polymorphism, which affects IgG binding affinity, is a risk factor for systemic lupus erythematosus (SLE). Methods. We genotyped a group of 70 Caucasian SLE patients for all known FcγR polymorphisms. Of this group, 45 patients (64%) had nephritis. In 35 patients, this diagnosis was confirmed by renal biopsy. Results. In the total group of 70 SLE patients, the frequency of the FcγRIIIA-158F allele was 0.74, versus 0.57 in healthy controls (P = 0.003). The genotype distribution of the FcγRIIIA-158V/F polymorphism was also significantly different from that of the control population (P = 0.004). The distribution of the other FcγR polymorphisms - FcγRIIA-131R/H, FcγRIIIB- NA(1,2), and FcγRIIIA-48L/R/H - was similar in SLE patients and controls. Conclusion. In our group of SLE patients, only the distribution of the alleles of the FcγRIIIA-158V/F polymorphism was significantly different from that in the control group. This might indicate that macrophage expression of the FcγRIIIA-158F isoform is involved in the disturbed clearance of immune complexes in patients with SLE.

Original languageEnglish (US)
Pages (from-to)1813-1818
Number of pages6
JournalArthritis and rheumatism
Issue number10
StatePublished - Oct 1998

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)


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