The fate of the 0.5s: Predictors of 2-year outcome in mild cognitive impairment

Eleni Aretouli, Ozioma C. Okonkwo, Jaclyn Samek, Jason Brandt

Research output: Contribution to journalArticlepeer-review

Abstract

Impairments in executive cognition (EC) may be predictive of incident dementia in patients with mild cognitive impairment (MCI). The present study examined whether specific EC tests could predict which MCI individuals progress from a Clinical Dementia Rating (CDR) score of 0.5 to a score ≥1 over a 2-year period. Eighteen clinical and experimental EC measures were administered at baseline to 104 MCI patients (amnestic and non-amnestic, single-and multiple-domain) recruited from clinical and research settings. Demographic characteristics, screening cognitive measures and measures of everyday functioning at baseline were also considered as potential predictors. Over the 2-year period, 18% of the MCI individuals progressed to CDR ≥ 1, 73.1% remained stable (CDR = 0.5), and 4.5% reverted to normal (CDR = 0). Multiple-domain MCI participants had higher rates of progression to dementia than single-domain, but amnestic and non-amnestic MCIs had similar rates of conversion. Only three EC measures were predictive of subsequent cognitive and functional decline at the univariate level, but they failed to independently predict progression to dementia after adjusting for demographic, other cognitive characteristics, and measures of everyday functioning. Decline over 2 years was best predicted by informant ratings of subtle functional impairments and lower baseline scores on memory, category fluency, and constructional praxis.

Original languageEnglish (US)
Pages (from-to)277-288
Number of pages12
JournalJournal of the International Neuropsychological Society
Volume17
Issue number2
DOIs
StatePublished - Mar 2011

Keywords

  • Clinical Dementia Rating scale
  • Dementia
  • Executive cognition
  • MCI outcome
  • Mild cognitive impairment
  • Predictors of decline

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Clinical Neurology
  • Psychiatry and Mental health

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