The "far left" of the morphologic spectrum of ovarian high-grade serous carcinoma: Case report of a purely noninvasive high-grade serous carcinoma mimicking an ovarian serous borderline tumor

Levon Katsakhyan, Ezra G. Baraban, Kimberly L. Dumoff, Robert A. Burger, Rupal Parikh, Kumarasen Cooper

Research output: Contribution to journalArticlepeer-review

Abstract

High-grade serous carcinoma has a variety of different growth patterns, but is typically easily recognizable to pathologists and rarely confused with serous borderline tumors. We report a case of a 71-yr-old woman with a unilateral 5.1 cm ovarian cyst with small papillary projections on contrast-enhanced magnetic resonance imaging of the pelvis. Histologic examination showed a noninvasive papillary neoplasm with hierarchical branching and epithelial proliferation, and thus, at low magnification, bearing a striking resemblance to a serous borderline tumor. However, a more careful examination demonstrated high-grade cytologic features, nuclear pleomorphism, and abundant mitotic activity, suggestive of high-grade serous carcinoma. The morphology and immunohistochemical profile of this lesion is consistent with a rare, purely noninvasive growth pattern of high-grade serous carcinoma. This lesion represents the "far left" of the high-grade ovarian serous carcinoma morphologic spectrum and can mimic a serous borderline tumor.

Original languageEnglish (US)
Pages (from-to)175-179
Number of pages5
JournalInternational Journal of Gynecological Pathology
Volume40
Issue number2
DOIs
StatePublished - Mar 2021
Externally publishedYes

Keywords

  • HGSC
  • High-grade serous carcinoma
  • Noninvasive ovarian high-grade serous carcinoma
  • P53 signature
  • Serous borderline tumor

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Obstetrics and Gynecology

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