TY - JOUR
T1 - The failure of furosemide-induced salt and water loss to convert benign to malignant hypertension in the rat
AU - Wilson, S. K.
AU - Solez, K.
AU - Heptinstall, R. H.
PY - 1980/12/1
Y1 - 1980/12/1
N2 - The concept has been advanced that malignant hypertension is precipitated in the rat with renal hypertension by a sudden loss of sodium in the urine. In order to test this hypothesis modest degrees of hypertension were produced in Holtzman rats by the application of a silver clip to one renal artery, not touching the opposite kidney. When the systolic blood pressure reached a level between 160 and 180 mm Hg, loss of sodium and water was induced by the administration of furosemide, given either orally over a 7-day period, or by 3 intramuscular injections over a 24-hour period. Sodium and water balance studies, blood pressure determinations, histologic assessment of blood vessels in the non-clipped kidney, and measurement of activity of the juxtaglomerular apparatus were carried out in these 2 groups and appropriate control animals. It was found that in spite of a considerable natriuresis and diuresis in furosemide-treated animals, there was neither a significant increase in blood pressure nor development of more severe vascular lesions in the nonclipped kidney than in the kidneys of control animals.
AB - The concept has been advanced that malignant hypertension is precipitated in the rat with renal hypertension by a sudden loss of sodium in the urine. In order to test this hypothesis modest degrees of hypertension were produced in Holtzman rats by the application of a silver clip to one renal artery, not touching the opposite kidney. When the systolic blood pressure reached a level between 160 and 180 mm Hg, loss of sodium and water was induced by the administration of furosemide, given either orally over a 7-day period, or by 3 intramuscular injections over a 24-hour period. Sodium and water balance studies, blood pressure determinations, histologic assessment of blood vessels in the non-clipped kidney, and measurement of activity of the juxtaglomerular apparatus were carried out in these 2 groups and appropriate control animals. It was found that in spite of a considerable natriuresis and diuresis in furosemide-treated animals, there was neither a significant increase in blood pressure nor development of more severe vascular lesions in the nonclipped kidney than in the kidneys of control animals.
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M3 - Article
C2 - 7435539
AN - SCOPUS:0019140022
SN - 0002-9440
VL - 101
SP - 303
EP - 318
JO - American Journal of Pathology
JF - American Journal of Pathology
IS - 2
ER -