The FaceBase Consortium: A comprehensive program to facilitate craniofacial research

Harry Hochheiser, Bruce J. Aronow, Kristin Artinger, Terri H. Beaty, James F. Brinkley, Yang Chai, David Clouthier, Michael L. Cunningham, Michael Dixon, Leah Rae Donahue, Scott E. Fraser, Benedikt Hallgrimsson, Junichi Iwata, Ophir Klein, Mary L. Marazita, Jeffrey C. Murray, Stephen Murray, Fernando Pardo Manuel de Villena, John Postlethwait, Steven PotterLinda Shapiro, Richard Spritz, Axel Visel, Seth M. Weinberg, Paul A. Trainor

Research output: Contribution to journalArticlepeer-review

Abstract

The FaceBase Consortium consists of ten interlinked research and technology projects whose goal is to generate craniofacial research data and technology for use by the research community through a central data management and integrated bioinformatics hub. Funded by the National Institute of Dental and Craniofacial Research (NIDCR) and currently focused on studying the development of the middle region of the face, the Consortium will produce comprehensive datasets of global gene expression patterns, regulatory elements and sequencing; will generate anatomical and molecular atlases; will provide human normative facial data and other phenotypes; conduct follow up studies of a completed genome-wide association study; generate independent data on the genetics of craniofacial development, build repositories of animal models and of human samples and data for community access and analysis; and will develop software tools and animal models for analyzing and functionally testing and integrating these data. The FaceBase website (http://www.facebase.org) will serve as a web home for these efforts, providing interactive tools for exploring these datasets, together with discussion forums and other services to support and foster collaboration within the craniofacial research community.

Original languageEnglish (US)
Pages (from-to)175-182
Number of pages8
JournalDevelopmental biology
Volume355
Issue number2
DOIs
StatePublished - Jul 15 2011

Keywords

  • Animal models
  • Cleft lip and palate
  • Craniofacial development
  • Database
  • Human genetics
  • Morphometrics

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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