The extensor carpi ulnaris pseudolesion: evaluation with microCT, histology, and MRI

Sayed Ali, Ryan Cunningham, Mamta Amin, Steven N. Popoff, Feroze Mohamed, Mary F. Barbe

Research output: Contribution to journalArticle

Abstract

Objective: To determine if magic angle plays a role in apparent central increased signal intensity of the distal extensor carpi ulnaris tendon (ECU) on MRI, to see if histologic findings of tendon degeneration are associated with increased T1 or T2 tendon signal on MR imaging, and to determine the prevalence of the ECU “pseudolesion”. Materials and methods: A standard 3 Tesla protocol was utilized to scan ten cadaveric wrists. A 40 mm length of 10 ECU and four extensor carpi radialis brevis (ECRB) tendons were immersion fixed before microCT scanning. Staining with Alcian blue, Masson’s trichrome and Safranin O was performed before light microscopy. Fifty clinical wrist MRIs were also reviewed for the presence of increased T1 and/or T2 signal. Results: Central increased T1 and/or T2 signal was observed in 9 of 10 cadaveric ECU tendons, but not in ECRB tendons. MicroCT and histology showed inter-tendinous matrix between the two distal heads of the ECU. Increased mucoid degeneration correlated with increased MRI signal intensity. The tendon fibers were at a maximum of 8.39° to the longitudinal axis on microCT. Clinical MRIs showed increased T1 signal in 6 %, increased T2 signal in 8 %, increased T1 and T2 signal in 80 %, and 6 % showing no increased signal. Conclusion: Central increased T1 and/or T2 signal in the ECU tendon indicates the presence of normal inter-tendinous ground substance, with increased proteoglycan content (mucoid degeneration) responsible for increased signal intensity. None of the fibers were shown on microCT to approach the magic angle.

Original languageEnglish (US)
Pages (from-to)1735-1743
Number of pages9
JournalSkeletal Radiology
Volume44
Issue number12
DOIs
StatePublished - Dec 1 2015

Keywords

  • Ground substance
  • Magic angle
  • Mucoid
  • Tendon

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Ali, S., Cunningham, R., Amin, M., Popoff, S. N., Mohamed, F., & Barbe, M. F. (2015). The extensor carpi ulnaris pseudolesion: evaluation with microCT, histology, and MRI. Skeletal Radiology, 44(12), 1735-1743. https://doi.org/10.1007/s00256-015-2224-3