The expression and role of human erythropoietin receptor in erythroid and nonerythroid cells

D. M. Williams, T. A. Zimmers, J. H. Pierce, P. N. Pharr, A. N. Schechter, S. T. Sawyer, S. K. Ruscetti, Jerry L Spivak, W. D. Hankins, A. D. D'Andrea, E. Goldwasser, M. J. Koury, W. D. Hankins, A. R. Migliaccio

Research output: Contribution to journalArticle

Abstract

In this paper we have discussed our recent progress on understanding the role of the EPOR in erythroid development. The major suggestions stemming from our studies are that (1) the EPOR conveys viability and/or proliferation but does not induce erythroid differentiation; (2) EPO-dependent cell lines (HC cells) provide a useful model for studies of the interaction of EPO with its receptor; (3) a highly glycosylated 78 kDa protein on the cell surface appears to be the mature, biologically active form of the EPO receptor; (4) the EPOR, when activated by ligand binding, may inhibit the induction of myeloid differentiation by G-CSF; and (5) the hormone sensitivity of leukemia cells may be exploited for the development of new approaches to target and deliver drugs that specifically control the growth of leukemia cells. In particular, a soluble form of EPOR bound EPO and inhibited EPO-dependent growth in vitro. Therefore this approach may also be useful as an antihormone therapy for erythroid leukemia in vivo.

Original languageEnglish (US)
Pages (from-to)232-244
Number of pages13
JournalAnnals of the New York Academy of Sciences
Volume718
StatePublished - 1994

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Erythropoietin Receptors
Erythroid Cells
Leukemia
Granulocyte Colony-Stimulating Factor
Drug and Narcotic Control
Cells
Hormones
Growth
Ligands
Membrane Proteins
Pharmaceutical Preparations
Cell Line
Proteins
Therapeutics

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Williams, D. M., Zimmers, T. A., Pierce, J. H., Pharr, P. N., Schechter, A. N., Sawyer, S. T., ... Migliaccio, A. R. (1994). The expression and role of human erythropoietin receptor in erythroid and nonerythroid cells. Annals of the New York Academy of Sciences, 718, 232-244.

The expression and role of human erythropoietin receptor in erythroid and nonerythroid cells. / Williams, D. M.; Zimmers, T. A.; Pierce, J. H.; Pharr, P. N.; Schechter, A. N.; Sawyer, S. T.; Ruscetti, S. K.; Spivak, Jerry L; Hankins, W. D.; D'Andrea, A. D.; Goldwasser, E.; Koury, M. J.; Hankins, W. D.; Migliaccio, A. R.

In: Annals of the New York Academy of Sciences, Vol. 718, 1994, p. 232-244.

Research output: Contribution to journalArticle

Williams, DM, Zimmers, TA, Pierce, JH, Pharr, PN, Schechter, AN, Sawyer, ST, Ruscetti, SK, Spivak, JL, Hankins, WD, D'Andrea, AD, Goldwasser, E, Koury, MJ, Hankins, WD & Migliaccio, AR 1994, 'The expression and role of human erythropoietin receptor in erythroid and nonerythroid cells', Annals of the New York Academy of Sciences, vol. 718, pp. 232-244.
Williams DM, Zimmers TA, Pierce JH, Pharr PN, Schechter AN, Sawyer ST et al. The expression and role of human erythropoietin receptor in erythroid and nonerythroid cells. Annals of the New York Academy of Sciences. 1994;718:232-244.
Williams, D. M. ; Zimmers, T. A. ; Pierce, J. H. ; Pharr, P. N. ; Schechter, A. N. ; Sawyer, S. T. ; Ruscetti, S. K. ; Spivak, Jerry L ; Hankins, W. D. ; D'Andrea, A. D. ; Goldwasser, E. ; Koury, M. J. ; Hankins, W. D. ; Migliaccio, A. R. / The expression and role of human erythropoietin receptor in erythroid and nonerythroid cells. In: Annals of the New York Academy of Sciences. 1994 ; Vol. 718. pp. 232-244.
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AU - Schechter, A. N.

AU - Sawyer, S. T.

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AU - Hankins, W. D.

AU - D'Andrea, A. D.

AU - Goldwasser, E.

AU - Koury, M. J.

AU - Hankins, W. D.

AU - Migliaccio, A. R.

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