TY - JOUR
T1 - The expanding significance of keratin intermediate filaments in normal and diseased epithelia
AU - Pan, Xiaoou
AU - Hobbs, Ryan P.
AU - Coulombe, Pierre A.
N1 - Funding Information:
We thank members of our laboratory for support. We apologize to those authors whose recent work could not be included in this review. This effort was made possible by grants AR44232 , AR42047 , and CA160255 (to P.A.C.) and T32CA009110 (to R.P.H.) from the National Institutes of Health .
PY - 2013/2
Y1 - 2013/2
N2 - Intermediate filaments are assembled from a diverse group of evolutionary conserved proteins and are specified in a tissue-dependent, cell type-dependent, and context-dependent fashion in the body. Genetic mutations in intermediate filament proteins account for a large number of diseases, ranging from skin fragility conditions to cardiomyopathies and premature aging. Keratins, the epithelial-specific intermediate filaments, are now recognized as multi-faceted effectors in their native context. In this review, we emphasize the recent progress made in defining the role of keratins towards the regulation of cytoarchitecture, cell growth and proliferation, apoptosis, and cell motility during embryonic development, in normal adult tissues, and in select diseases such as cancer.
AB - Intermediate filaments are assembled from a diverse group of evolutionary conserved proteins and are specified in a tissue-dependent, cell type-dependent, and context-dependent fashion in the body. Genetic mutations in intermediate filament proteins account for a large number of diseases, ranging from skin fragility conditions to cardiomyopathies and premature aging. Keratins, the epithelial-specific intermediate filaments, are now recognized as multi-faceted effectors in their native context. In this review, we emphasize the recent progress made in defining the role of keratins towards the regulation of cytoarchitecture, cell growth and proliferation, apoptosis, and cell motility during embryonic development, in normal adult tissues, and in select diseases such as cancer.
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U2 - 10.1016/j.ceb.2012.10.018
DO - 10.1016/j.ceb.2012.10.018
M3 - Review article
C2 - 23270662
AN - SCOPUS:84873731727
SN - 0955-0674
VL - 25
SP - 47
EP - 56
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
IS - 1
ER -