The expanding significance of keratin intermediate filaments in normal and diseased epithelia

Xiaoou Pan, Ryan P. Hobbs, Pierre A. Coulombe

Research output: Contribution to journalReview article

Abstract

Intermediate filaments are assembled from a diverse group of evolutionary conserved proteins and are specified in a tissue-dependent, cell type-dependent, and context-dependent fashion in the body. Genetic mutations in intermediate filament proteins account for a large number of diseases, ranging from skin fragility conditions to cardiomyopathies and premature aging. Keratins, the epithelial-specific intermediate filaments, are now recognized as multi-faceted effectors in their native context. In this review, we emphasize the recent progress made in defining the role of keratins towards the regulation of cytoarchitecture, cell growth and proliferation, apoptosis, and cell motility during embryonic development, in normal adult tissues, and in select diseases such as cancer.

Original languageEnglish (US)
Pages (from-to)47-56
Number of pages10
JournalCurrent Opinion in Cell Biology
Volume25
Issue number1
DOIs
StatePublished - Feb 2013

ASJC Scopus subject areas

  • Cell Biology

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