The evolving role of proteomics in the early detection of breast cancer

Timothy M. Pawlik, Henry M. Kuerer

Research output: Contribution to journalArticle

Abstract

There has been emerging interest in the examination of tumor protein expression (proteomics) as a means to identify novel diagnostic and therapeutic targets in women with breast cancer. Specifically, several investigators have examined biological fluids (serum and breast ductal fluid) and breast tissue in an attempt to detect novel proteomic profiles in women with breast carcinoma. The current tools of proteomic research are evolving, but include two-dimensional polyacrylamide gel electrophoresis and mass spectrometry. Initial studies have identified several unique biomarkers and proteomic profiles that were able to discriminate between non-cancer and breast cancer patients. In the future, the application of large-scale proteomic technology may provide a means of early detection, surveillance, and identification of potential therapeutic targets.

Original languageEnglish (US)
Pages (from-to)212-216
Number of pages5
JournalInternational Journal of Fertility and Women's Medicine
Volume50
Issue number5
Publication statusPublished - 2005
Externally publishedYes

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Keywords

  • Electrophoresis (diagnostic)
  • Mass spectrometry (SELDI MS, SELDI TOF)

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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