The evolutionary dynamics of the lion Panthera leo revealed by host and viral population genomics

Agostinho Antunes, Jennifer L. Troyer, Melody E. Roelke, Jill Pecon-Slattery, Craig Packer, Christiaan Winterbach, Hanlie Winterbach, Graham Hemson, Laurence Frank, Philip Stander, Ludwig Siefert, Margaret Driciru, Paul J. Funston, Kathy A. Alexander, Katherine C. Prager, Gus Mills, David Wildt, Mitch Bush, Stephen J. O'Brien, Warren E. Johnson

Research output: Contribution to journalArticle

Abstract

The lion Panthera leo is one of the world's most charismatic carnivores and is one of Africa's key predators. Here, we used a large dataset from 357 lions comprehending 1.13 megabases of sequence data and genotypes from 22 microsatellite loci to characterize its recent evolutionary history. Patterns of molecular genetic variation in multiple maternal (mtDNA), paternal (Y-chromosome), and biparental nuclear (nDNA) genetic markers were compared with patterns of sequence and subtype variation of the lion feline immunodeficiency virus (FIVPle), a lentivirus analogous to human immunodeficiency virus (HIV). In spite of the ability of lions to disperse long distances, patterns of lion genetic diversity suggest substantial population subdivision (mtDNA ΦST = 0.92; nDNA FST = 0.18), and reduced gene flow, which, along with large differences in sero-prevalence of six distinct FIVPle subtypes among lion populations, refute the hypothesis that African lions consist of a single panmictic population. Our results suggest that extant lion populations derive from several Pleistocene refugia in East and Southern Africa (∼324,000-169,000 years ago), which expanded during the Late Pleistocene (∼100,000 years ago) into Central and North Africa and into Asia. During the Pleistocene/Holocene transition (∼14,000-7,000 years), another expansion occurred from southern refugia northwards towards East Africa, causing population interbreeding. In particular, lion and FIVPle variation affirms that the large, well-studied lion population occupying the greater Serengeti Ecosystem is derived from three distinct populations that admixed recently.

Original languageEnglish (US)
Article numbere1000251
JournalPLoS Genetics
Volume4
Issue number11
DOIs
StatePublished - Nov 2008
Externally publishedYes

Fingerprint

Lions
Metagenomics
Panthera leo
genomics
Pleistocene
refugium
genetic marker
human immunodeficiency virus
carnivore
gene flow
Population
genetic variation
chromosome
virus
genotype
Holocene
predator
Eastern Africa
ecosystem
refuge habitats

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Ecology, Evolution, Behavior and Systematics
  • Cancer Research
  • Genetics(clinical)

Cite this

Antunes, A., Troyer, J. L., Roelke, M. E., Pecon-Slattery, J., Packer, C., Winterbach, C., ... Johnson, W. E. (2008). The evolutionary dynamics of the lion Panthera leo revealed by host and viral population genomics. PLoS Genetics, 4(11), [e1000251]. https://doi.org/10.1371/journal.pgen.1000251

The evolutionary dynamics of the lion Panthera leo revealed by host and viral population genomics. / Antunes, Agostinho; Troyer, Jennifer L.; Roelke, Melody E.; Pecon-Slattery, Jill; Packer, Craig; Winterbach, Christiaan; Winterbach, Hanlie; Hemson, Graham; Frank, Laurence; Stander, Philip; Siefert, Ludwig; Driciru, Margaret; Funston, Paul J.; Alexander, Kathy A.; Prager, Katherine C.; Mills, Gus; Wildt, David; Bush, Mitch; O'Brien, Stephen J.; Johnson, Warren E.

In: PLoS Genetics, Vol. 4, No. 11, e1000251, 11.2008.

Research output: Contribution to journalArticle

Antunes, A, Troyer, JL, Roelke, ME, Pecon-Slattery, J, Packer, C, Winterbach, C, Winterbach, H, Hemson, G, Frank, L, Stander, P, Siefert, L, Driciru, M, Funston, PJ, Alexander, KA, Prager, KC, Mills, G, Wildt, D, Bush, M, O'Brien, SJ & Johnson, WE 2008, 'The evolutionary dynamics of the lion Panthera leo revealed by host and viral population genomics', PLoS Genetics, vol. 4, no. 11, e1000251. https://doi.org/10.1371/journal.pgen.1000251
Antunes A, Troyer JL, Roelke ME, Pecon-Slattery J, Packer C, Winterbach C et al. The evolutionary dynamics of the lion Panthera leo revealed by host and viral population genomics. PLoS Genetics. 2008 Nov;4(11). e1000251. https://doi.org/10.1371/journal.pgen.1000251
Antunes, Agostinho ; Troyer, Jennifer L. ; Roelke, Melody E. ; Pecon-Slattery, Jill ; Packer, Craig ; Winterbach, Christiaan ; Winterbach, Hanlie ; Hemson, Graham ; Frank, Laurence ; Stander, Philip ; Siefert, Ludwig ; Driciru, Margaret ; Funston, Paul J. ; Alexander, Kathy A. ; Prager, Katherine C. ; Mills, Gus ; Wildt, David ; Bush, Mitch ; O'Brien, Stephen J. ; Johnson, Warren E. / The evolutionary dynamics of the lion Panthera leo revealed by host and viral population genomics. In: PLoS Genetics. 2008 ; Vol. 4, No. 11.
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