The evolution of the surgical treatment of chronic pancreatitis

Dana K. Andersen, Charles F. Frey

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: To establish the current status of surgical therapy for chronic pancreatitis, recent published reports are examined in the context of the historical advances in the field. BACKGROUND: The basis for decompression (drainage), denervation, and resection strategies for the treatment of pain caused by chronic pancreatitis is reviewed. These divergent approaches have finally coalesced as the head of the pancreas has become apparent as the nidus of chronic inflammation. METHODS: The recent developments in surgical methods to treat the complications of chronic pancreatitis and the results of recent prospective randomized trials of operative approaches were reviewed to establish the current best practices. RESULTS: Local resection of the pancreatic head, with or without duct drainage, and duodenum-preserving pancreatic head resection offer outcomes as effective as pancreaticoduodenectomy, with lowered morbidity and mortality. Local resection or excavation of the pancreatic head offers the advantage of lowest cost and morbidity and early prevention of postoperative diabetes. The late incidences of recurrent pain, diabetes, and exocrine insufficiency are equivalent for all 3 surgical approaches. CONCLUSIONS: Local resection of the pancreatic head appears to offer best outcomes and lowest risk for the management of the pain of chronic pancreatitis.

Original languageEnglish (US)
Pages (from-to)18-32
Number of pages15
JournalAnnals of Surgery
Volume251
Issue number1
DOIs
StatePublished - Jan 2010

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Chronic Pancreatitis
Pain
Drainage
Morbidity
Pancreaticoduodenectomy
Risk Management
Denervation
Therapeutics
Decompression
Duodenum
Practice Guidelines
Pancreas
Inflammation
Costs and Cost Analysis
Mortality
Incidence

ASJC Scopus subject areas

  • Surgery

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The evolution of the surgical treatment of chronic pancreatitis. / Andersen, Dana K.; Frey, Charles F.

In: Annals of Surgery, Vol. 251, No. 1, 01.2010, p. 18-32.

Research output: Contribution to journalArticle

Andersen, Dana K. ; Frey, Charles F. / The evolution of the surgical treatment of chronic pancreatitis. In: Annals of Surgery. 2010 ; Vol. 251, No. 1. pp. 18-32.
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