Abstract
Molecular imaging allows for the remote, noninvasive sensing and measurement of cellular and molecular processes in living subjects. Drawing upon a variety of modalities, molecular imaging provides a window into the biology of cancer from the subcellular level to the patient undergoing a new, experimental therapy. As signal transduction cascades and protein interaction networks become clarified, an increasing number of relevant targets for cancer therapy-and imaging-become available. Although conventional imaging is already critical to the management of patients with cancer, molecular imaging will provide even more relevant information, such as early detection of changes with therapy, identification of patient-specific cellular and metabolic abnormalities, and the disposition of therapeutic, gene-tagged cells throughout the body-all of which will have a considerable impact on morbidity and mortality. This overview discusses molecular imaging in oncology, providing examples from a variety of modalities, with an emphasis on emerging techniques for translational imaging.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3-15 |
| Number of pages | 13 |
| Journal | Seminars in Oncology |
| Volume | 38 |
| Issue number | 1 |
| DOIs | |
| State | Published - Feb 2011 |
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ASJC Scopus subject areas
- Oncology
- Hematology
Cite this
The evolution of imaging in cancer : Current state and future challenges. / Higgins, Luke J.; Pomper, Martin Gilbert.
In: Seminars in Oncology, Vol. 38, No. 1, 02.2011, p. 3-15.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The evolution of imaging in cancer
T2 - Current state and future challenges
AU - Higgins, Luke J.
AU - Pomper, Martin Gilbert
PY - 2011/2
Y1 - 2011/2
N2 - Molecular imaging allows for the remote, noninvasive sensing and measurement of cellular and molecular processes in living subjects. Drawing upon a variety of modalities, molecular imaging provides a window into the biology of cancer from the subcellular level to the patient undergoing a new, experimental therapy. As signal transduction cascades and protein interaction networks become clarified, an increasing number of relevant targets for cancer therapy-and imaging-become available. Although conventional imaging is already critical to the management of patients with cancer, molecular imaging will provide even more relevant information, such as early detection of changes with therapy, identification of patient-specific cellular and metabolic abnormalities, and the disposition of therapeutic, gene-tagged cells throughout the body-all of which will have a considerable impact on morbidity and mortality. This overview discusses molecular imaging in oncology, providing examples from a variety of modalities, with an emphasis on emerging techniques for translational imaging.
AB - Molecular imaging allows for the remote, noninvasive sensing and measurement of cellular and molecular processes in living subjects. Drawing upon a variety of modalities, molecular imaging provides a window into the biology of cancer from the subcellular level to the patient undergoing a new, experimental therapy. As signal transduction cascades and protein interaction networks become clarified, an increasing number of relevant targets for cancer therapy-and imaging-become available. Although conventional imaging is already critical to the management of patients with cancer, molecular imaging will provide even more relevant information, such as early detection of changes with therapy, identification of patient-specific cellular and metabolic abnormalities, and the disposition of therapeutic, gene-tagged cells throughout the body-all of which will have a considerable impact on morbidity and mortality. This overview discusses molecular imaging in oncology, providing examples from a variety of modalities, with an emphasis on emerging techniques for translational imaging.
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U2 - 10.1053/j.seminoncol.2010.11.010
DO - 10.1053/j.seminoncol.2010.11.010
M3 - Article
VL - 38
SP - 3
EP - 15
JO - Seminars in Oncology
JF - Seminars in Oncology
SN - 0093-7754
IS - 1
ER -