The Evi1, microRNA-143, K-Ras axis in colon cancer

Jin Song Gao, Yingjie Zhang, Xiaoli Tang, Lynne D. Tucker, Patrick M. Tarwater, Peter J. Quesenberry, Isidore Rigoutsos, Bharat Ramratnam

Research output: Contribution to journalArticlepeer-review

Abstract

MicroRNA profiling of diseased/non-diseased tissue has identified expression signatures associated with a wide range of pathogenic conditions including malignancy. For example, colon cancer is associated with the under expression of miRNA-143 yet the molecular etiology of under expression is unknown. The K-Ras oncogene is a target of miRNA-143. Here, we show that the ecotropic viral integration site 1 oncoprotein (Evi1) is a transcriptional suppressor of the miRNA-143 gene. We find an indirect relationship between miRNA-143 and Evi1 expression. A complex molecular axis linking Evi1, miRNA-143 is operational in human colon cancer.

Original languageEnglish (US)
Pages (from-to)693-699
Number of pages7
JournalFEBS Letters
Volume585
Issue number4
DOIs
StatePublished - Feb 18 2011
Externally publishedYes

Keywords

  • Colon cancer
  • Evi1
  • MicroRNA
  • RNA interference

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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