The Evi1, microRNA-143, K-Ras axis in colon cancer

Jin Song Gao; Yingjie Zhang; Xiaoli Tang; Lynne D. Tucker; Patrick M. Tarwater; Peter J. Quesenberry; Isidore Rigoutsos; Bharat Ramratnam

doi:10.1016/j.febslet.2011.01.033

The Evi1, microRNA-143, K-Ras axis in colon cancer

Jin Song Gao, Yingjie Zhang, Xiaoli Tang, Lynne D. Tucker, Patrick M. Tarwater, Peter J. Quesenberry, Isidore Rigoutsos, Bharat Ramratnam

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

MicroRNA profiling of diseased/non-diseased tissue has identified expression signatures associated with a wide range of pathogenic conditions including malignancy. For example, colon cancer is associated with the under expression of miRNA-143 yet the molecular etiology of under expression is unknown. The K-Ras oncogene is a target of miRNA-143. Here, we show that the ecotropic viral integration site 1 oncoprotein (Evi1) is a transcriptional suppressor of the miRNA-143 gene. We find an indirect relationship between miRNA-143 and Evi1 expression. A complex molecular axis linking Evi1, miRNA-143 is operational in human colon cancer.

Original language	English (US)
Pages (from-to)	693-699
Number of pages	7
Journal	FEBS Letters
Volume	585
Issue number	4
DOIs	https://doi.org/10.1016/j.febslet.2011.01.033
State	Published - Feb 18 2011
Externally published	Yes

Keywords

Colon cancer
Evi1
MicroRNA
RNA interference

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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10.1016/j.febslet.2011.01.033

Cite this

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title = "The Evi1, microRNA-143, K-Ras axis in colon cancer",

abstract = "MicroRNA profiling of diseased/non-diseased tissue has identified expression signatures associated with a wide range of pathogenic conditions including malignancy. For example, colon cancer is associated with the under expression of miRNA-143 yet the molecular etiology of under expression is unknown. The K-Ras oncogene is a target of miRNA-143. Here, we show that the ecotropic viral integration site 1 oncoprotein (Evi1) is a transcriptional suppressor of the miRNA-143 gene. We find an indirect relationship between miRNA-143 and Evi1 expression. A complex molecular axis linking Evi1, miRNA-143 is operational in human colon cancer.",

keywords = "Colon cancer, Evi1, MicroRNA, RNA interference",

author = "Gao, {Jin Song} and Yingjie Zhang and Xiaoli Tang and Tucker, {Lynne D.} and Tarwater, {Patrick M.} and Quesenberry, {Peter J.} and Isidore Rigoutsos and Bharat Ramratnam",

note = "Funding Information: This work was supported by a Clinical Scientist Development award from the Doris Duke Charitable Foundation (B.R.). We thank the Lifespan/Tufts/Brown CFAR{\textquoteright}s Retrovirology Services Laboratory ( NIHP30AI042853 ), the Center for Cancer Research Development ( NIHP20RR017695 ) and the Center for Stem Cell Biology ( P20RR018757 ) for assay support. XT was supported by a training grant from National Institutes of Health ( T32DA013911 ) ",

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doi = "10.1016/j.febslet.2011.01.033",

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AU - Gao, Jin Song

AU - Zhang, Yingjie

AU - Tang, Xiaoli

AU - Tucker, Lynne D.

AU - Tarwater, Patrick M.

AU - Quesenberry, Peter J.

AU - Rigoutsos, Isidore

AU - Ramratnam, Bharat

N1 - Funding Information: This work was supported by a Clinical Scientist Development award from the Doris Duke Charitable Foundation (B.R.). We thank the Lifespan/Tufts/Brown CFAR’s Retrovirology Services Laboratory ( NIHP30AI042853 ), the Center for Cancer Research Development ( NIHP20RR017695 ) and the Center for Stem Cell Biology ( P20RR018757 ) for assay support. XT was supported by a training grant from National Institutes of Health ( T32DA013911 )

PY - 2011/2/18

Y1 - 2011/2/18

N2 - MicroRNA profiling of diseased/non-diseased tissue has identified expression signatures associated with a wide range of pathogenic conditions including malignancy. For example, colon cancer is associated with the under expression of miRNA-143 yet the molecular etiology of under expression is unknown. The K-Ras oncogene is a target of miRNA-143. Here, we show that the ecotropic viral integration site 1 oncoprotein (Evi1) is a transcriptional suppressor of the miRNA-143 gene. We find an indirect relationship between miRNA-143 and Evi1 expression. A complex molecular axis linking Evi1, miRNA-143 is operational in human colon cancer.

AB - MicroRNA profiling of diseased/non-diseased tissue has identified expression signatures associated with a wide range of pathogenic conditions including malignancy. For example, colon cancer is associated with the under expression of miRNA-143 yet the molecular etiology of under expression is unknown. The K-Ras oncogene is a target of miRNA-143. Here, we show that the ecotropic viral integration site 1 oncoprotein (Evi1) is a transcriptional suppressor of the miRNA-143 gene. We find an indirect relationship between miRNA-143 and Evi1 expression. A complex molecular axis linking Evi1, miRNA-143 is operational in human colon cancer.

KW - Colon cancer

KW - Evi1

KW - MicroRNA

KW - RNA interference

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The Evi1, microRNA-143, K-Ras axis in colon cancer

Abstract

Keywords

ASJC Scopus subject areas

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