The European Society for Blood and Marrow Transplantation (EBMT) Consensus Guidelines for the Detection and Treatment of Donor-specific Anti-HLA Antibodies (DSA) in Haploidentical Hematopoietic Cell Transplantation

Stefan O. Ciurea; Kai Cao; Marcelo Fernadez-Vina; Piyanuch Kongtim; Monzr Al Malki; Ephraim Fuchs; Leo Luznik; Xiao Jun Huang; Fabio Ciceri; Franco Locatelli; Franco Aversa; Luca Castagna; Andrea Bacigalupo; Massimo Martelli; Didier Blaise; Rupert Handgretinger; Denis Claude Roy; Paul O'Donnell; Asad Bashey; Hillard M. Lazarus; Karen Ballen; Bipin N. Savani; Mohamad Mohty; Arnon Nagler

doi:10.1038/s41409-017-0062-8

The European Society for Blood and Marrow Transplantation (EBMT) Consensus Guidelines for the Detection and Treatment of Donor-specific Anti-HLA Antibodies (DSA) in Haploidentical Hematopoietic Cell Transplantation

Stefan O. Ciurea, Kai Cao, Marcelo Fernadez-Vina, Piyanuch Kongtim, Monzr Al Malki, Ephraim Fuchs, Leo Luznik, Xiao Jun Huang, Fabio Ciceri, Franco Locatelli, Franco Aversa, Luca Castagna, Andrea Bacigalupo, Massimo Martelli, Didier Blaise, Rupert Handgretinger, Denis Claude Roy, Paul O'Donnell, Asad Bashey, Hillard M. LazarusKaren Ballen, Bipin N. Savani, Mohamad Mohty, Arnon Nagler

School of Medicine

Research output: Contribution to journal › Review article › peer-review

68 Scopus citations

Abstract

Haploidentical donors are now increasingly considered for transplantation in the absence of HLA-matched donors or when an urgent transplant is needed. Donor-specific anti-HLA antibodies (DSA) have been recently recognized as an important barrier against successful engraftment of donor cells, which can affect transplant survival. DSA appear more prevalent in this type of transplant due to higher likelihood of alloimmunization of multiparous females against offspring's HLA antigens, and the degree of mismatch. Here we summarize the evidence for the role of DSA in the development of primary graft failure in haploidentical transplantation and provide consensus recommendations from the European Society for Blood and Marrow Transplant Group on testing, monitoring, and treatment of patients with DSA receiving haploidentical hematopoietic progenitor cell transplantation.

Original language	English (US)
Pages (from-to)	521-534
Number of pages	14
Journal	Bone marrow transplantation
Volume	53
Issue number	5
DOIs	https://doi.org/10.1038/s41409-017-0062-8
State	Published - May 1 2018

ASJC Scopus subject areas

Hematology
Transplantation

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Ciurea, S. O., Cao, K., Fernadez-Vina, M., Kongtim, P., Malki, M. A., Fuchs, E., Luznik, L., Huang, X. J., Ciceri, F., Locatelli, F., Aversa, F., Castagna, L., Bacigalupo, A., Martelli, M., Blaise, D., Handgretinger, R., Roy, D. C., O'Donnell, P., Bashey, A., ... Nagler, A. (2018). The European Society for Blood and Marrow Transplantation (EBMT) Consensus Guidelines for the Detection and Treatment of Donor-specific Anti-HLA Antibodies (DSA) in Haploidentical Hematopoietic Cell Transplantation. Bone marrow transplantation, 53(5), 521-534. https://doi.org/10.1038/s41409-017-0062-8

The European Society for Blood and Marrow Transplantation (EBMT) Consensus Guidelines for the Detection and Treatment of Donor-specific Anti-HLA Antibodies (DSA) in Haploidentical Hematopoietic Cell Transplantation. / Ciurea, Stefan O.; Cao, Kai; Fernadez-Vina, Marcelo et al.
In: Bone marrow transplantation, Vol. 53, No. 5, 01.05.2018, p. 521-534.

Research output: Contribution to journal › Review article › peer-review

Ciurea, SO, Cao, K, Fernadez-Vina, M, Kongtim, P, Malki, MA, Fuchs, E , Luznik, L, Huang, XJ, Ciceri, F, Locatelli, F, Aversa, F, Castagna, L, Bacigalupo, A, Martelli, M, Blaise, D, Handgretinger, R, Roy, DC, O'Donnell, P, Bashey, A, Lazarus, HM, Ballen, K, Savani, BN, Mohty, M & Nagler, A 2018, 'The European Society for Blood and Marrow Transplantation (EBMT) Consensus Guidelines for the Detection and Treatment of Donor-specific Anti-HLA Antibodies (DSA) in Haploidentical Hematopoietic Cell Transplantation', Bone marrow transplantation, vol. 53, no. 5, pp. 521-534. https://doi.org/10.1038/s41409-017-0062-8

Ciurea SO, Cao K, Fernadez-Vina M, Kongtim P, Malki MA, Fuchs E et al. The European Society for Blood and Marrow Transplantation (EBMT) Consensus Guidelines for the Detection and Treatment of Donor-specific Anti-HLA Antibodies (DSA) in Haploidentical Hematopoietic Cell Transplantation. Bone marrow transplantation. 2018 May 1;53(5):521-534. doi: 10.1038/s41409-017-0062-8

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AU - Roy, Denis Claude

AU - O'Donnell, Paul

AU - Bashey, Asad

AU - Lazarus, Hillard M.

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AU - Savani, Bipin N.

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The European Society for Blood and Marrow Transplantation (EBMT) Consensus Guidelines for the Detection and Treatment of Donor-specific Anti-HLA Antibodies (DSA) in Haploidentical Hematopoietic Cell Transplantation

Abstract

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