The etiopathogenesis of Parkinson disease and suggestions for future research. Part II

Irene Litvan; Marie Francoise Chesselet; Thomas Gasser; Donato A. Di Monte; Davis Parker; Theo Hagg; John Hardy; Peter Jenner; Richard H. Myers; Donald Price; Mark Hallett; William J. Langston; Anthony E. Lang; Glenda Halliday; Walter Rocca; Charles Duyckaerts; Dennis W. Dickson; Yoav Ben-Shlomo; Christopher G. Goetz; Eldad Melamed

doi:10.1097/nen.0b013e318053716a

The etiopathogenesis of Parkinson disease and suggestions for future research. Part II

Irene Litvan, Marie Francoise Chesselet, Thomas Gasser, Donato A. Di Monte, Davis Parker, Theo Hagg, John Hardy, Peter Jenner, Richard H. Myers, Donald Price, Mark Hallett, William J. Langston, Anthony E. Lang, Glenda Halliday, Walter Rocca, Charles Duyckaerts, Dennis W. Dickson, Yoav Ben-Shlomo, Christopher G. Goetz, Eldad Melamed

School of Medicine

Research output: Contribution to journal › Review article › peer-review

35 Scopus citations

Abstract

We are at a critical juncture in our knowledge of the etiology and pathogenesis of Parkinson disease (PD). It is clear that PD is not a single entity simply resulting from a dopaminergic deficit; rather it is most likely caused by a combination of genetic and environmental factors. Although there is extensive new information on the etiology and pathogenesis of PD, which may advance its treatment, new syntheses of this information are needed. The second part of this two-part, state-of-the-art review by leaders in PD research critically examines the research field to identify areas for which new knowledge and ideas might be helpful for treatment purposes. Topics reviewed in Part II are genetics, animal models, and oxidative stress.

Original language	English (US)
Pages (from-to)	329-336
Number of pages	8
Journal	Journal of neuropathology and experimental neurology
Volume	66
Issue number	5
DOIs	https://doi.org/10.1097/nen.0b013e318053716a
State	Published - May 2007

Keywords

Lewy bodies
Parkinson disease
Synucleinopathies

ASJC Scopus subject areas

Pathology and Forensic Medicine
Neurology
Clinical Neurology
Cellular and Molecular Neuroscience

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10.1097/nen.0b013e318053716a

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Litvan, I., Chesselet, M. F., Gasser, T., Di Monte, D. A., Parker, D., Hagg, T., Hardy, J., Jenner, P., Myers, R. H., Price, D., Hallett, M., Langston, W. J., Lang, A. E., Halliday, G., Rocca, W., Duyckaerts, C., Dickson, D. W., Ben-Shlomo, Y., Goetz, C. G., & Melamed, E. (2007). The etiopathogenesis of Parkinson disease and suggestions for future research. Part II. Journal of neuropathology and experimental neurology, 66(5), 329-336. https://doi.org/10.1097/nen.0b013e318053716a

Litvan, I, Chesselet, MF, Gasser, T, Di Monte, DA, Parker, D, Hagg, T, Hardy, J, Jenner, P, Myers, RH, Price, D, Hallett, M, Langston, WJ, Lang, AE, Halliday, G, Rocca, W, Duyckaerts, C, Dickson, DW, Ben-Shlomo, Y, Goetz, CG & Melamed, E 2007, 'The etiopathogenesis of Parkinson disease and suggestions for future research. Part II', Journal of neuropathology and experimental neurology, vol. 66, no. 5, pp. 329-336. https://doi.org/10.1097/nen.0b013e318053716a

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The etiopathogenesis of Parkinson disease and suggestions for future research. Part II

Abstract

Keywords

ASJC Scopus subject areas

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